PubRank

M E Wall

Author PubWeight™ 86.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 1971 8.56
2 Germination of Witchweed (Striga lutea Lour.): Isolation and Properties of a Potent Stimulant. Science 1966 2.57
3 DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science 1989 2.11
4 Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum. J Nat Prod 2001 1.97
5 Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 1989 1.71
6 Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women. Clin Pharmacol Ther 1983 1.44
7 DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res 1989 1.40
8 Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse. Science 1971 1.34
9 Presence of delta9-tetrahydrocannabinol in human milk. N Engl J Med 1982 1.26
10 Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. Cancer Res 1991 1.20
11 Metabolism and disposition of naltrexone in man after oral and intravenous administration. Drug Metab Dispos 1981 1.13
12 Two isoflavones from the bark of Petalostemon purpureus. Phytochemistry 1996 1.09
13 Antitrypanosomal activity of camptothecin analogs. Structure-activity correlations. Biochem Pharmacol 1995 1.06
14 Two isoflavones from the bark of Petalostemon purpureus. Phytochemistry 1996 1.05
15 Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. J Med Chem 1980 1.05
16 Pharmacology of orally administered 9 -tetrahydrocannabinol. Clin Pharmacol Ther 1973 1.05
17 Intravenous injection in man of 9 -tetrahydrocannabinol and 11-OH- 9 -tetrahydrocannabinol. Science 1972 1.05
18 Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites. Proc Natl Acad Sci U S A 1995 1.04
19 Lipid bilayer partitioning and stability of camptothecin drugs. Biochemistry 1993 1.01
20 Biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man. Drug Metab Dispos 1978 0.99
21 Determinants of bistability in induction of the Escherichia coli lac operon. IET Syst Biol 2008 0.97
22 Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase. J Nat Prod 1994 0.96
23 The metabolism and toxicity of halogenated carbanilides. Biliary metabolites of 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide in the rat. Drug Metab Dispos 1977 0.94
24 Bioactive constituents of the roots of Licania intrapetiolaris. J Nat Prod 2001 0.94
25 The metabolism of delta 9-tetrahydrocannabinol and related cannabinoids in man. J Clin Pharmacol 1982 0.94
26 Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem 1969 0.93
27 High-resolution macromolecular structure determination using CCD detectors and synchrotron radiation. Structure 1995 0.92
28 Comparative molecular field analysis and molecular modeling studies of 20-(S)-camptothecin analogs as inhibitors of DNA topoisomerase I and anticancer/antitumor agents. J Comput Aided Mol Des 1997 0.91
29 Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. J Med Chem 1986 0.90
30 Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother 1999 0.90
31 New bioactive aromatic compounds from Vismia guianensis. Phytochemistry 2000 0.89
32 Isolation, structure, and biological activity of several metabolites of delta-9-tetrahydrocannabinol. J Am Chem Soc 1970 0.87
33 Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography. J Nat Prod 2001 0.87
34 Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells. Mol Pharmacol 1997 0.87
35 Selected papers from the First q-bio Conference on Cellular Information Processing. IET Syst Biol 2008 0.86
36 Metabolic removal of a 17-alpha-ethynyl group from the antifertility steroid, norethindrone. J Pharmacol Exp Ther 1969 0.85
37 Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations. J Med Chem 1987 0.85
38 The Third q-bio Conference on Cellular Information Processing. IET Syst Biol 2010 0.85
39 Synthesis of 11-hydroxy- 6 -tetrahydrocannabinol and other physiologically active metabolites of 8 - and 9 -tetrahydrocannabinol. J Am Chem Soc 1972 0.85
40 A model of troponin-I in complex with troponin-C using hybrid experimental data: the inhibitory region is a beta-hairpin. Protein Sci 2000 0.85
41 Selective drug resistant human osteosarcoma cell lines. Clin Orthop Relat Res 2001 0.85
42 Identification of 9 -tetrahydrocannabinol and metabolites in man. J Am Chem Soc 1972 0.85
43 Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera. J Nat Prod 1995 0.84
44 Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts. Cancer Res 1999 0.82
45 Camptothecin analogues with enhanced antitumor activity at acidic pH. Cancer Chemother Pharmacol 2000 0.81
46 Letter: Antitumor agents. XIII. Isolation and absolute configuration of carminomycin I from Streptosporangium sp. J Am Chem Soc 1975 0.81
47 The metabolism of R(+)- and RS-pentobarbital. J Pharmacol Exp Ther 1969 0.81
48 The effectof norethynodrel, norethindrone and ethynodiol diacetate on hepatic microsomal drug metabolism. Pharmacol Res Commun 1974 0.81
49 7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents. Mol Pharmacol 2000 0.81
50 POTASSIUM DEFICIENCY IN AMMONIUM-AND NITRATE-FED TOMATO PLANTS. Science 1940 0.80
51 The synthesis of (-)-delta-9(11)-trans-tetrahydrocannabinol. J Org Chem 1971 0.80
52 Metabolism of optically active barbiturates. II. S (-)--pentobarbital. J Pharmacol Exp Ther 1970 0.80
53 Human DNA topoisomerase I: quantitative analysis of the effects of camptothecin analogs and the benzophenanthridine alkaloids nitidine and 6-ethoxydihydronitidine on DNA topoisomerase I-induced DNA strand breakage. Arch Biochem Biophys 1999 0.80
54 The metabolism of naltrexone in man. NIDA Res Monogr 1981 0.80
55 Carbon-13 magnetic resonance study. Structure of the metabolites of orally administered quinidine in humans. J Med Chem 1974 0.79
56 The metabolism of ethynodiol diacetate by rat and human liver. J Pharmacol Exp Ther 1971 0.79
57 Antitumor and antileukemic effects of some steroids and other biologically interesting compounds containing an alkylating agent. J Med Chem 1972 0.79
58 A comparative study of the oral, intravenous, and subcutaneous administration of 3H-naltrexone to normal male volunteers. NIDA Res Monogr 1981 0.79
59 Flavonoids. IV. A novel Clemmensen reduction. The direct conversion of 2-alkylisoflavones to 2-alkyl-delta-3-isoflavenes. J Org Chem 1967 0.79
60 The effects of some steroidal alkylating agents on experimental animal mammary tumor and leukemia systems. J Med Chem 1969 0.78
61 Stem cell transplantation for metastatic breast cancer: analysis of tumor contamination. Med Oncol 1999 0.78
62 Simple isolation of antimycin A1 and some of its toxicological properties. Appl Microbiol 1969 0.78
63 Phencyclidine disposition after intravenous and oral doses. Clin Pharmacol Ther 1982 0.78
64 The metabolism of antifertility steroids. The in virto metabolism of chlormadinone acetate. Drug Metab Dispos 1974 0.77
65 Isolation and structural elucidation of pentacyclic triterpenoids from Maprounea africana. J Nat Prod 1995 0.77
66 Norethynodrel metabolites in human plasma and urine. J Pharmacol Exp Ther 1972 0.77
67 Plant antitumor agents. IX. The total synthesis of dl-camptothecin. J Am Chem Soc 1972 0.77
68 Distribution of delta 9-tetrahydrocannabinol in the mouse. Br J Pharmacol 1972 0.77
69 A complex pattern of disposition of phenytoin in severe intoxication. Clin Pharmacol Ther 1975 0.77
70 Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity. J Med Chem 1986 0.77
71 Isolation and structure identification of an active DNA strand-scission agent, (+)-3,4-di-hydroxy-8,9-methylenedioxypterocarpan. J Nat Prod 1995 0.77
72 New biphenyl compounds with DNA strand-scission activity from Clusia paralicola. J Nat Prod 1999 0.77
73 Metabolism of antifertility steroids. I. Norethynodrel. J Pharmacol Exp Ther 1969 0.77
74 Steroids. LXXIX. Synthesis and reactions of oxiranes obtained from 3- and 17-keto steroids. J Org Chem 1968 0.76
75 Antineoplastic agents from plants. Annu Rev Pharmacol Toxicol 1977 0.76
76 Plant antitumor agents, 21. Flavones, coumarins, and an alkaloid from Sargentia greggii. J Nat Prod 1986 0.76
77 Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes. Leuk Res 1999 0.76
78 Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex. Mol Cancer Ther 2001 0.76
79 Naltrexone disposition in man after subcutaneous administration. Drug Metab Dispos 1985 0.76
80 Plant antitumor agents, 19. Novel triterpenes from Maprounea africana. J Nat Prod 1983 0.76
81 Two isoflavones from the bark of Petalostemon purpureus. Phytochemistry 1996 0.75
82 Preparation of 9-tetrahydrocannabinol for intravenous injection. J Pharm Pharmacol 1973 0.75
83 Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. J Med Chem 1990 0.75
84 A reinvestigation of Maprounea triterpenes. J Nat Prod 1995 0.75
85 Isolation and chemical characterization of antitumor agents from plants. Cancer Treat Rep 1976 0.75
86 Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. J Med Chem 1987 0.75
87 Variability in St. John's wort formulations is an important consideration. Altern Ther Health Med 2001 0.75
88 Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora. Lloydia 1979 0.75
89 Triterpenes from the combined leaf and stem of Lithospermum caroliniense. Phytochemistry 1996 0.75
90 Analytical methods for the determination of cannabinoids in biological media. NIDA Res Monogr 1976 0.75
91 Metabolism of norethynodrel in thrombophlebitic-thromboembolic subjects. Experientia 1975 0.75
92 Steroids. 78. The lead tetraacetate oxidation of a 5-hydroxy-B-norsteroid. Tetrahedron 1967 0.75
93 Cytotoxic constituents from the roots of Tovomita brevistaminea. Phytochemistry 1999 0.75
94 Steroids LXXVI. Stereospecific formation of alpha- and beta-epoxides in the reaction of dimethylsulfonium methylide and dimethylsulfoxonium methylide with dihydrotestosterone. Tetrahedron Lett 1965 0.75
95 Plant antitumor agents. 17. Structural requirements for antineoplastic activity in quassinoids. J Med Chem 1978 0.75
96 Plant antitumor agents. 3. A convenient separation of tannins from other plant constituents. J Pharm Sci 1969 0.75
97 Two new aromatic constitutents from the rootwood of Aeschynomene mimosifolia. J Nat Prod 1996 0.75
98 Elimination of radioactivity from rats after intravenous administration of phenyl-labeled [14C]- or [3H]phencyclidine hydrochloride. Drug Metab Dispos 1982 0.75
99 Plant antimutagenic agents, 5. Isolation and structure of two new isoflavones, fremontin and fremontone from Psorothamnus fremontii. J Nat Prod 1989 0.75
100 N-substituted aminoethanethiols and N-substituted aminoethanethiol S-sulfonic acids as radioprotective agents. J Pharm Sci 1970 0.75
101 Plant antitumor agents. X. The total synthesis of a ring DE analog of camptothecin. J Am Chem Soc 1972 0.75
102 Long-term use of marihuana and the development of tolerance or sensitivity to delta9 tetrahydrocannabinol. Arch Gen Psychiatry 1974 0.75
103 Smoking of phencyclidine: disposition in man and stability to pyrolytic conditions. Life Sci 1981 0.75
104 Flavonoids. V. Thiation of isoflavones. J Med Chem 1967 0.75
105 Metabolism and distribution of norethynodrel in pregnant and nonpregnant mice. Toxicol Appl Pharmacol 1973 0.75
106 Analytical methods for quantitative and qualitative analysis of naltrexone and metabolites in biological fluids. NIDA Res Monogr 1981 0.75
107 The whole body distribution of norethindrone, ethynodiol diacetate and progesterone in the pregnant mouse. J Pharmacol Exp Ther 1972 0.75
108 Identity of maprounic acid with aleuritolic acid. Revision of the structure of maprounic acid: X-ray crystal structure of p-bromobenzyl acetylmaprounate. J Nat Prod 1989 0.75
109 Species and strain differences in the epimerization of 3-beta, 17-beta-dihydroxy-17-alpha-ethynyl-delta-5 (10)-estrene to the 3 alpha-hydroxy epimer. Biochem Pharmacol 1971 0.75
110 Norethindrone plasma levels in human subjects. Life Sci 1974 0.75
111 Effects of two metabolites of norethynodrel on reproductive performance of female rats. Fertil Steril 1970 0.75
112 The preparation of 3-alpha- and 3-beta,17-beta-Dihydroxy-17-alpha-ethynyl-estr-5(10)-ene. Steroids 1969 0.75
113 Teratogenic and other effects produced in mice by norethynodrel and its 3-hydroxymetabolites. Teratology 1970 0.75
114 The synthesis of beta-amino mercaptans and beta-amino thiosulfates via ethylenimine intermediates. J Org Chem 1965 0.75
115 A comparison of the pharmacological activity of delta 9-tetrahydrocannabinol and its monohydroxylated metabolites in man. Experientia 1973 0.75
116 Steroids. LXXVII. A novel rearrangement in an alcohol-lead tetraacetate reaction. Tetrahedron Lett 1965 0.75
117 Comparison of gas chromatography mass spectrometry methods for the determination of delta9-tetrahydrocannabinol in plasma. Biomed Mass Spectrom 1978 0.75
118 Cholesteryl esters in flue-cured tobacco. Experientia 1967 0.75
119 Flavonoids. 3. Studies on the synthesis of 2,4-dialkyl-7-acetoxy-4'-methoxy-delta-3-isoflavenes. J Org Chem 1967 0.75
120 The metabolic fate of orally administered quinidine gluconate in humans. Biochem Pharmacol 1969 0.75
121 The synthesis of 6-chloro-17-hydroxpregna-4,6-diene-3,20-dione-4-14C acetate (Chlormadinone-4-C acetate). J Labelled Compd 1980 0.75
122 Epimerization of an intermediary metabolite of norethynodrel by a 3 beta-hydroxy-delta 5(10)-steroid epimerase. Biochem Pharmacol 1971 0.75
123 New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii. J Nat Prod 1998 0.75
124 A new prenylated flavonol from the root of Petalostemon purpureus. J Nat Prod 1996 0.75
125 The preparation and analysis of enriched and pure cannabinoids from marihuana and hashish. Lloydia 1970 0.75
126 Ampicillin induced septum formation in Bacillus cereus. Microbios 1983 0.75
127 Ethynodiol diacetate metabolites in human plasma. J Pharmacol Exp Ther 1973 0.75
128 Applications of mass spectrometry in cannabinoid research. Adv Biosci 1980 0.75
129 Independent Research Institutes. Science 1963 0.75
130 Metabolism of norethynodrel by rat liver. Biochem Pharmacol 1971 0.75