Published in Genes Dev on January 01, 2015
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Paused RNA polymerase II inhibits new transcriptional initiation. Nat Genet (2017) 1.41
Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways. Trends Biochem Sci (2015) 0.96
PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Cell (2015) 0.96
RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition. Nucleic Acids Res (2015) 0.86
Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. PLoS Genet (2016) 0.82
Fabrication of novel vesicles of triptolide for antirheumatoid activity with reduced toxicity in vitro and in vivo. Int J Nanomedicine (2016) 0.79
RNA polymerase II pausing as a context-dependent reader of the genome. Biochem Cell Biol (2015) 0.77
Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity. BMC Genomics (2015) 0.76
TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment. J Cancer (2016) 0.75
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A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
RNA polymerase is poised for activation across the genome. Nat Genet (2007) 9.57
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet (2007) 9.56
Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc (2006) 7.29
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell (1999) 6.34
Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science (2008) 5.48
In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes. Proc Natl Acad Sci U S A (1993) 4.82
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat Rev Genet (2012) 4.37
Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell (2010) 4.28
Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock. Mol Cell Biol (2003) 3.65
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev (2003) 3.65
Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II. Cell (1994) 3.61
mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription. Mol Cell (2012) 2.57
The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev (2012) 2.55
Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo. Cell (2013) 2.42
Global regulation of promoter melting in naive lymphocytes. Cell (2013) 2.05
Control of transcriptional elongation. Annu Rev Genet (2013) 1.92
XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol (2011) 1.89
Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. Genes Dev (2011) 1.87
Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs. Cell (2014) 1.85
Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons. Elife (2014) 1.82
Contacts in context: promoter specificity and macromolecular interactions in transcription. Cell (1996) 1.80
The transition from transcriptional initiation to elongation. Curr Opin Genet Dev (2008) 1.78
The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77
Functional association of Gdown1 with RNA polymerase II poised on human genes. Mol Cell (2012) 1.56
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII. Cell (2012) 1.49
The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol (2012) 1.49
Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals. Mol Cell (2013) 1.36
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond. Biochim Biophys Acta (2012) 1.31
Structural insights into transcription initiation by RNA polymerase II. Trends Biochem Sci (2013) 1.27
Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing. Mol Cell (2013) 1.19
Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II. Mol Cell (2012) 1.18
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II. Cancer Res (2012) 1.03
Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II). PLoS One (2011) 1.02
Transcriptional elongation checkpoint control in development and disease. Genes Dev (2013) 0.98
Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation. Genes Dev (2014) 0.94
The multifunctional RNase XRN2. Biochem Soc Trans (2013) 0.89
Get back TFIIF, don't let me Gdown1. Mol Cell (2012) 0.84
Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity. Genes Dev (2016) 0.83