Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 25568836)

Published in Mult Scler Relat Disord on March 01, 2014

Authors

Adaikalavan Ramasamy1, Daniah Trabzuni2, Paola Forabosco3, Colin Smith4, Robert Walker4, Allissa Dillman5, Sigurlaug Sveinbjornsdottir6, North American Brain Expression Consortium (NABEC), UK Brain Expression Consortium (UKBEC), John Hardy7, Michael E Weale8, Mina Ryten1

Author Affiliations

1: King's College London, Department of Medical & Molecular Genetics, Guy's Hospital, London SE1 9RT, UK ; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, England, UK.
2: Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, England, UK ; Department of Genetics, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia.
3: Istituto di Genetica delle Popolazioni - CNR, Sassari, Italy.
4: Department of Neuropathology, MRC Sudden Death Brain Bank Project, University of Edinburgh, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, UK.
5: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
6: Department of Neurology, MEHT, Broomfield Hospital, Court Road, CM1 7ET Essex, UK ; Department of Neurology, Queen Mary College, University of London, UK.
7: Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, England, UK.
8: King's College London, Department of Medical & Molecular Genetics, Guy's Hospital, London SE1 9RT, UK.

Articles cited by this

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41

Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64

WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58

Multiple sclerosis. Lancet (2008) 13.77

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74

Multiple sclerosis. Lancet (2002) 7.11

Functional organization of the transcriptome in human brain. Nat Neurosci (2008) 7.02

Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol (2008) 5.08

The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007. Cell Tissue Bank (2008) 4.13

A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data. Nucleic Acids Res (2009) 3.50

A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet (2011) 3.16

Is my network module preserved and reproducible? PLoS Comput Biol (2011) 2.91

Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies. J Neurochem (2011) 2.82

Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci U S A (2003) 2.50

Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol (2011) 2.07

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Hum Mol Genet (2012) 1.58

The initiation and prevention of multiple sclerosis. Nat Rev Neurol (2012) 1.58

Tissue and organ donation for research in forensic pathology: the MRC Sudden Death Brain and Tissue Bank. J Pathol (2007) 1.51

Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiol Aging (2013) 1.49

Measurement and clinical effect of grey matter pathology in multiple sclerosis. Lancet Neurol (2012) 1.47

Concordance for multiple sclerosis in Danish twins: an update of a nationwide study. Mult Scler (2005) 1.46

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiol Dis (2012) 1.35

Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron (2011) 1.34

Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies. Nucleic Acids Res (2013) 1.25

Vitamin D and multiple sclerosis: epidemiology, immunology, and genetics. Curr Opin Neurol (2012) 1.09

No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol (2013) 0.87

No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis. Ann Neurol (2013) 0.84