Published in Mol Cell on January 08, 2015
Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature (2017) 1.48
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nat Cell Biol (2016) 1.02
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun (2016) 0.89
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
Autophagic activity in neuronal cell death. Neurosci Bull (2015) 0.86
Emerging roles of PtdIns(4,5)P2 - beyond the plasma membrane. J Cell Sci (2015) 0.84
Lipid droplet-mediated ER homeostasis regulates autophagy and cell survival during starvation. J Cell Biol (2016) 0.84
Coxiella burnetii effector CvpB modulates phosphoinositide metabolism for optimal vacuole development. Proc Natl Acad Sci U S A (2016) 0.84
Guidelines for the Use of Protein Domains in Acidic Phospholipid Imaging. Methods Mol Biol (2016) 0.83
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget (2016) 0.83
Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation. Biophys J (2016) 0.82
Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy. Autophagy (2015) 0.82
PtdIns(4,5)P2 signaling regulates ATG14 and autophagy. Proc Natl Acad Sci U S A (2016) 0.79
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. Mol Cell (2016) 0.79
Arf6 and the 5'phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors. Inside Cell (2016) 0.76
Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiol Rep (2016) 0.76
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest (2016) 0.76
LRRK2 at the interface of autophagosomes, endosomes and lysosomes. Mol Neurodegener (2016) 0.76
Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells. J Am Soc Nephrol (2016) 0.76
Mirror image phosphoinositides regulate autophagy. Mol Cell Oncol (2015) 0.76
Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity. J Leukoc Biol (2016) 0.76
Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways. Int J Mol Sci (2017) 0.75
Septins As Modulators of Endo-Lysosomal Membrane Traffic. Front Cell Dev Biol (2016) 0.75
Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis (2016) 0.75
Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis. Commun Integr Biol (2016) 0.75
VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta (2016) 0.75
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget (2017) 0.75
Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance. Sci Rep (2017) 0.75
Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS One (2017) 0.75
High mobility group A1 protein modulates autophagy in cancer cells. Cell Death Differ (2017) 0.75
Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis. J Cell Sci (2017) 0.75
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem (2000) 8.68
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem (1997) 6.09
The role of autophagy in neurodegenerative disease. Nat Med (2013) 4.46
In search of an "autophagomometer". Autophagy (2009) 4.31
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol (2007) 3.29
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature (1997) 3.29
Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy (2010) 2.91
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ (2008) 2.89
Human VPS34 is required for internal vesicle formation within multivesicular endosomes. J Cell Biol (2001) 2.63
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci (2008) 2.55
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A (2010) 2.53
Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev Mol Cell Biol (2011) 2.52
Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol (2011) 2.38
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep (2008) 2.09
Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy. EMBO J (2009) 2.07
Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J Cell Biol (1998) 1.97
A molecular investigation of true dominance in Huntington's disease. J Med Genet (1999) 1.92
PI3P signaling regulates receptor sorting but not transport in the endosomal pathway. J Cell Biol (2003) 1.90
PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem (1999) 1.79
Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. Biochem J (1997) 1.60
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic (2010) 1.59
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell (2004) 1.57
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell (2014) 1.45
Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization. J Biol Chem (2001) 1.40
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
PIKfyve regulation of endosome-linked pathways. Traffic (2009) 1.39
Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell (2012) 1.37
A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J (2010) 1.34
Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy (2013) 1.33
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice. J Biol Chem (2011) 1.32
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One (2013) 1.28
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy (2011) 1.17
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D. J Cell Biol (2012) 1.16
Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Biochem J (2001) 1.13
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc Natl Acad Sci U S A (2013) 1.09
Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J Immunol (2009) 1.06
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling. Bioessays (2013) 1.06
AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal (2013) 1.03
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One (2013) 1.00
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep (2012) 0.98
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. Am J Physiol Cell Physiol (2012) 0.96
Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha. FEBS Lett (2008) 0.94
Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. Proc Natl Acad Sci U S A (2012) 0.91
Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics. Bioessays (2013) 0.90
Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1. Nat Commun (2014) 0.90
Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases. Adv Enzyme Regul (2009) 0.88
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochem J (2014) 0.87
PtdIns5P: news and views of its appearance, disappearance and deeds. Arch Biochem Biophys (2013) 0.86
Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Sci Rep (2013) 0.82
Regulation of PIKfyve phosphorylation by insulin and osmotic stress. Biochem Biophys Res Commun (2010) 0.82
Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem J (2013) 0.81
Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways. FEBS Lett (2010) 0.79
Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases. Adv Enzyme Regul (2009) 0.88