Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulations.

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Published in Biophys J on January 20, 2015

Authors

Steffen Lindert1, Yuanhua Cheng2, Peter Kekenes-Huskey3, Michael Regnier2, J Andrew McCammon4

Author Affiliations

1: Department of Pharmacology, University of California San Diego, La Jolla, California; NSF Center for Theoretical Biological Physics, La Jolla, California. Electronic address: slindert@ucsd.edu.
2: Department of Bioengineering, University of Washington, Seattle, Washington.
3: Department of Pharmacology, University of California San Diego, La Jolla, California; Department of Chemistry, University of Kentucky, Lexington, Kentucky.
4: Department of Pharmacology, University of California San Diego, La Jolla, California; Howard Hughes Medical Institute, University of California San Diego, La Jolla, California; Department of Chemistry and Biochemistry, National Biomedical Computation Resource, University of California San Diego, La Jolla, California; NSF Center for Theoretical Biological Physics, La Jolla, California.

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