Methylation of MGMT and ADAMTS14 in normal colon MUCOSA: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.

Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications. Cancer Prev Res (Phila) (2016) 0.78

Tumor size is an independent risk predictor for metachronous colorectal cancer. Oncotarget (2016) 0.77

LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer. Oncotarget (2015) 0.77

Epigenetic Basis of Cancer Health Disparities: Looking Beyond Genetic Differences. Biochim Biophys Acta (2017) 0.76

Second German-Catalan workshop on epigenetics & cancer. Epigenetics (2015) 0.75

Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer. Clin Epigenetics (2015) 0.75

Integrated transcriptomic analysis of distance-related field cancerization in rectal cancer patients. Oncotarget (2017) 0.75

Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13

The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A (1996) 29.54

Lessons from hereditary colorectal cancer. Cell (1996) 25.73

World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA (2013) 20.79

High sensitivity mapping of methylated cytosines. Nucleic Acids Res (1994) 16.62

Cancer. p53, guardian of the genome. Nature (1992) 16.36

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15

CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (1993) 12.74

COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res (1997) 9.94

Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res (1997) 8.88

RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res (1999) 6.10

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature (1987) 5.46

MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst (2005) 5.22

5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science (1990) 4.80

A comprehensive survey of Ras mutations in cancer. Cancer Res (2012) 3.67

The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol (2005) 3.48

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells. Proc Natl Acad Sci U S A (1985) 3.29

MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer (2004) 3.27

Interplay between the cancer genome and epigenome. Cell (2013) 3.05

Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell (2006) 2.89

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res (2000) 2.79

Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer (2011) 2.77

The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. Nucleic Acids Res (1994) 2.37

Cancers exhibit a mutator phenotype: clinical implications. Cancer Res (2008) 2.36

Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell (2003) 2.24

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene (2002) 2.05

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res (2001) 1.97

Cancer of the microsatellite mutator phenotype. Biol Chem (1996) 1.91

The mutation rate and cancer. Genetics (1998) 1.88

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer (2004) 1.72

Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers. Gut (2010) 1.71

Predisposition to neoplastic transformation caused by gene replacement of H-ras1. Science (1993) 1.69

ras oncogenes: their role in neoplasia. Eur J Clin Invest (1990) 1.68

Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res (2008) 1.64

Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene (2003) 1.47

A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget (2013) 1.27

Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma. J Clin Oncol (2006) 1.18

Diagnostic and therapeutic applications of epigenetics. Jpn J Clin Oncol (2005) 1.17

Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. Gastroenterology (1999) 1.11

Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA. Cancer Res (1997) 1.07

Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes. Mol Cell Biol (1986) 1.01

O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions. Gut (2005) 1.01

Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. Cancer (2010) 0.99

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis. Front Biosci (Landmark Ed) (2011) 0.99

Roles of the DNA mismatch repair genes in colorectal tumorigenesis. Int J Cancer (1996) 0.95

ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis. BMB Rep (2013) 0.95

Colorectal cancer disparities: issues, controversies and solutions. World J Gastroenterol (2014) 0.95

Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. Clin Cancer Res (2013) 0.91

Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor. World J Gastroenterol (2005) 0.89

Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells. Oncotarget (2014) 0.85

Toward a Molecular Classification of Colorectal Cancer: The Role of MGMT. Front Oncol (2013) 0.84

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era. Oncotarget (2014) 0.81