Published in Toxicol Sci on February 17, 2015
Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes. Basic Clin Pharmacol Toxicol (2015) 0.84
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs. Sci Rep (2016) 0.76
Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells. Pharmaceutics (2016) 0.75
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability. Sci Rep (2016) 0.75
Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model. Sci Rep (2016) 0.75
Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance. Hum Cell (2017) 0.75
Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56
Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev (2009) 5.11
Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev (2003) 3.07
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem (1998) 2.72
Molecular pathogenesis of cholestasis. N Engl J Med (1998) 2.68
Bile salt transporters. Annu Rev Physiol (2002) 1.94
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology (2001) 1.92
Bile Acids: The Good, the Bad, and the Ugly. News Physiol Sci (1999) 1.81
Mechanisms and regulation of bile secretion. Hepatology (1991) 1.74
Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology (2002) 1.72
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol (1993) 1.72
Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metab Rev (2010) 1.52
Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs. Pharm Res (2009) 1.46
Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. Am J Physiol (1999) 1.45
Hepatic transport of bile salts. Semin Liver Dis (2000) 1.31
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos (2009) 1.25
Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology (2007) 1.23
Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis (2010) 1.22
High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver. Cell Biol Int Rep (1982) 1.18
General review on in vitro hepatocyte models and their applications. Methods Mol Biol (2010) 1.17
Trafficking of canalicular ABC transporters in hepatocytes. Annu Rev Physiol (2002) 1.09
Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicol Sci (2003) 1.08
Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology (1997) 1.05
Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver. J Pharmacol Exp Ther (2003) 1.03
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatology (2013) 1.02
Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. Semin Liver Dis (2010) 1.00
Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. Mol Pharm (2007) 1.00
Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity. PLoS One (2013) 0.96
Expression and transport function of drug uptake transporters in differentiated HepaRG cells. Mol Pharm (2012) 0.95
Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes. Toxicol Appl Pharmacol (2012) 0.93
Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C. Hepatology (2010) 0.92
Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human. Toxicol Sci (2010) 0.92
Drug-induced liver injury: the role of drug metabolism and transport. J Clin Pharmacol (2013) 0.91
Optimization of the HepaRG cell model for drug metabolism and toxicity studies. Toxicol In Vitro (2012) 0.90
Canalicular export pumps traffic with polymeric immunoglobulin A receptor on the same microtubule-associated vesicle in rat liver. J Biol Chem (1999) 0.90
Oxidative stress: a radical way to stop making bile. Ann Hepatol (2008) 0.90
JC-1: a very sensitive fluorescent probe to test Pgp activity in adult acute myeloid leukemia. Blood (2001) 0.88
Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. Toxicol Sci (2006) 0.87
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B. BMC Physiol (2005) 0.87
Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity. Expert Opin Drug Metab Toxicol (2013) 0.86
Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci (2014) 0.86
Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells. Toxicol Sci (2014) 0.84
Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicol In Vitro (2013) 0.84
Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye. Toxicol Appl Pharmacol (2011) 0.83
Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. Drug Metab Dispos (2014) 0.80
The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions. Drug Metab Dispos (2014) 0.76