Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.

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🔗 View Article (PMID 25695691)

Published in Clin Cancer Res on February 18, 2015

Authors

Steven G DuBois1, Susan Groshen2, Julie R Park3, Daphne A Haas-Kogan4, Xiaodong Yang4, Ethan Geier5, Eugene Chen5, Kathy Giacomini5, Brian Weiss6, Susan L Cohn7, M Meaghan Granger8, Gregory A Yanik9, Randall Hawkins10, Jesse Courtier10, Hollie Jackson11, Fariba Goodarzian11, Hiroyuki Shimada12, Scarlett Czarnecki13, Denice Tsao-Wei2, Judith G Villablanca13, Araz Marachelian13, Katherine K Matthay14

Author Affiliations

1: Department of Pediatrics, University of California San Francisco, San Francisco, California. duboiss@peds.ucsf.edu.
2: Department of Preventive Medicine, USC Keck School of Medicine and Children's Hospital Los Angeles, Los Angeles, California.
3: Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
4: Department of Radiation Oncology, University of California San Francisco, San Francisco, California.
5: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California.
6: Department of Pediatrics, Cincinnati Children's Medical Center, Cincinnati, Ohio.
7: Department of Pediatrics, University of Chicago School of Medicine, Chicago, Illinois.
8: Department of Pediatrics, Cook Children's Hospital, Fort Worth, Texas.
9: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan.
10: Department of Radiology, University of California San Francisco, San Francisco, California.
11: Department of Radiology, USC Keck School of Medicine and Children's Hospital Los Angeles, Los Angeles, California.
12: Department of Pathology, USC Keck School of Medicine and Children's Hospital Los Angeles, Los Angeles, California.
13: Department of Pediatrics, USC Keck School of Medicine and Children's Hospital Los Angeles, Los Angeles, California.
14: Department of Pediatrics, University of California San Francisco, San Francisco, California.

Associated clinical trials:

131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinistat (N2011-01) | NCT02035137

N2007-03: Vorinostat and 131-I MIBG in Treating Patients With Resistant or Relapsed Neuroblastoma | NCT01019850

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