Published in Aliment Pharmacol Ther on February 23, 2015
TAK-438 - Safety, Blood Levels & Effects of Repeated Doses (TAK-438_107) | NCT02141711
The binding selectivity of vonoprazan (TAK-438) to the gastric H(+) ,K(+) -ATPase. Aliment Pharmacol Ther (2015) 1.96
Randomised clinical trial: vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis. Aliment Pharmacol Ther (2015) 1.08
Randomised clinical trial: a dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis. Aliment Pharmacol Ther (2015) 1.04
Potassium-Competitive Acid Blockers (P-CABs): Are They Finally Ready for Prime Time in Acid-Related Disease? Clin Transl Gastroenterol (2015) 0.92
The Efficacy and Tolerability of a Triple Therapy Containing a Potassium-Competitive Acid Blocker Compared With a 7-Day PPI-Based Low-Dose Clarithromycin Triple Therapy. Am J Gastroenterol (2016) 0.85
Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa. Dig Dis Sci (2016) 0.81
Effect of proton pump inhibitors on glycemic control in patients with diabetes. World J Diabetes (2015) 0.81
Usefulness of vonoprazan, a potassium ion-competitive acid blocker, for primary eradication of Helicobacter pylori. World J Gastrointest Pharmacol Ther (2016) 0.75
Pharmacokinetic Drug-Drug Interactions Between Vonoprazan and Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drugs: A Phase 2, Open-Label, Study in Healthy Japanese Men. Clin Drug Investig (2017) 0.75
Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy. World J Gastroenterol (2017) 0.75
Vonoprazan-based therapy for Helicobacter pylori eradication: experience and clinical evidence. Therap Adv Gastroenterol (2016) 0.75
Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers. World J Gastrointest Endosc (2016) 0.75
Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial. Can J Gastroenterol Hepatol (2017) 0.75
A randomized, double-blind study to evaluate the acid-inhibitory effect of vonoprazan (20 mg and 40 mg) in patients with proton-pump inhibitor-resistant erosive esophagitis. Therap Adv Gastroenterol (2017) 0.75
Effect of Vonoprazan, a Potassium-Competitive Acid Blocker, on the (13)C-Urea Breath Test in Helicobacter pylori-Positive Patients. Dig Dis Sci (2017) 0.75
Appropriate acid suppression for the management of gastro-oesophageal reflux disease. Digestion (1992) 1.95
1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther (2010) 1.40
A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease. Am J Gastroenterol (2008) 1.27
Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438). J Pharmacol Exp Ther (2011) 1.26
The gastric H,K ATPase as a drug target: past, present, and future. J Clin Gastroenterol (2007) 1.20
A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther (2011) 1.16
Efficacy of esomeprazole 40 mg vs. lansoprazole 30 mg for healing moderate to severe erosive oesophagitis. Aliment Pharmacol Ther (2005) 1.15
A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol (2011) 1.12
The new proton pump inhibitor esomeprazole is effective as a maintenance therapy in GERD patients with healed erosive oesophagitis: a 6-month, randomized, double-blind, placebo-controlled study of efficacy and safety. Aliment Pharmacol Ther (2001) 1.03
Chronic hypergastrinemia: causes and consequences. Dig Dis Sci (2007) 1.02
Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease. World J Gastroenterol (2013) 1.01
Acid peptic diseases: pharmacological approach to treatment. Expert Rev Clin Pharmacol (2009) 1.00
Intragastric acid suppression and pharmacokinetics of twice-daily esomeprazole: a randomized, three-way crossover study. Aliment Pharmacol Ther (2004) 1.00
Review article: the opportunities and benefits of extended acid suppression. Aliment Pharmacol Ther (2006) 0.96
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem (2012) 0.96
Molecular mechanisms in therapy of acid-related diseases. Cell Mol Life Sci (2008) 0.95
A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). Ther Clin Risk Manag (2007) 0.94
Long lasting inhibitors of the gastric H,K-ATPase. Expert Rev Clin Pharmacol (2009) 0.86
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers. Bioorg Med Chem (2012) 0.86
Nocturnal acid breakthrough - approach to management. MedGenMed (2004) 0.86
Serum pepsinogens after interruption of long-term maintenance therapy with omeprazole in patients with reflux esophagitis. Dig Dis Sci (1993) 0.80
An integrative model for the study of developmental competencies in minority children. Child Dev (1996) 9.23
Green revolution: a mutant gibberellin-synthesis gene in rice. Nature (2002) 5.84
Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid. J Bacteriol (1999) 5.65
A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun (1997) 5.25
Cloning and structural analyses of hepatitis B virus DNAs, subtype adr. Nucleic Acids Res (1983) 4.94
Nucleotide sequence of Escherichia coli K-12 replication origin. Proc Natl Acad Sci U S A (1979) 4.85
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res (1981) 4.30
Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology. Lancet (1995) 3.99
Socioeconomic status, standard of living, and neurotic disorder. Lancet (1998) 3.80
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet (1995) 3.76
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet (2002) 3.67
IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum. Neurology (2010) 3.34
Cyclic ADP-ribose in insulin secretion from pancreatic beta cells. Science (1993) 3.26
Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer. J Neurosci (2000) 3.24
EXPERIMENTS IN HUMAN VOLUNTEERS WITH TRACHOMA AND INCLUSION CONJUNCTIVITIS AGENT. Br J Ophthalmol (1962) 3.18
Infection with hepatitis GB virus C in patients on maintenance hemodialysis. N Engl J Med (1996) 3.13
High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin. Dev Biol (1997) 3.03
Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene (1999) 3.01
Factors influencing the development and amelioration of suicidal thoughts in the general population. Cohort study. Br J Psychiatry (2004) 2.95
A study of the classification of mental ill-health in general practice. Psychol Med (1985) 2.88
Murein-lipoprotein of Escherichia coli: a protein involved in the stabilization of bacterial cell envelope. Mol Gen Genet (1978) 2.84
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res (1982) 2.82
TOPS: an internet-based system to prevent healthy subjects from over-volunteering for clinical trials. Eur J Clin Pharmacol (2012) 2.80
The Satisfaction with Information about Medicines Scale (SIMS): a new measurement tool for audit and research. Qual Health Care (2001) 2.79
The twelve-month outcome of patients with neurotic illness in general practice. Psychol Med (1981) 2.74
Amino acid sequence of human von Willebrand factor. Biochemistry (1986) 2.73
A novel gene activated in regenerating islets. J Biol Chem (1988) 2.71
A novel recovery system for cultured cells using plasma-treated polystyrene dishes grafted with poly(N-isopropylacrylamide). J Biomed Mater Res (1993) 2.67
Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res (2000) 2.67
Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998. Jpn J Infect Dis (1999) 2.52
Silencing of retrotransposons in arabidopsis and reactivation by the ddm1 mutation. Plant Cell (2000) 2.50
Progressive cerebral atrophy in MS: a serial study using registered, volumetric MRI. Neurology (2000) 2.47
How are nations trying to prevent suicide? An analysis of national suicide prevention strategies. Acta Psychiatr Scand (1997) 2.45
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood (2001) 2.39
The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev (1997) 2.38
Hepatitis C virus infection in spouses of patients with type C chronic liver disease. Ann Intern Med (1994) 2.38
Midline signals regulate retinal neurogenesis in zebrafish. Neuron (2000) 2.37
Hepatitis C virus infection in medical personnel after needlestick accident. Hepatology (1992) 2.37
Minor psychiatric morbidity in employed young men and women and its contribution to sickness absence. Br J Ind Med (1985) 2.36
Minor psychiatric morbidity and the threat of redundancy in a professional group. Psychol Med (1982) 2.36
Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Lancet (1990) 2.35
Membrane currents of the tunicate egg under the voltage-clamp condition. J Physiol (1976) 2.32
Construction of an ordered cosmid collection of the Escherichia coli K-12 W3110 chromosome. J Bacteriol (1989) 2.28
Translational control of proinsulin synthesis by glucose. Nature (1980) 2.23
Two components of the calcium current in the egg cell membrane of the tunicate. J Physiol (1976) 2.22
Synthetic ColE1 plasmids carrying genes for cell division in Escherichia coli. Plasmid (1977) 2.22
Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene. Hum Mol Genet (2001) 2.15
FIN219, an auxin-regulated gene, defines a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development. Genes Dev (2000) 2.11
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. Neurology (2001) 2.09
Unequal access and unmet need: neurotic disorders and the use of primary care services. Psychol Med (2000) 2.08
First case of H-type bovine spongiform encephalopathy identified in Great Britain. Vet Rec (2007) 2.08
Long-term outcome of patients with neurotic illness in general practice. BMJ (1996) 2.08
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest (2001) 2.07
Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol (1994) 2.05
Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces. Biomaterials (1995) 2.04
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets. Nature (1981) 2.02
Nicotine, alcohol and drug dependence and psychiatric comorbidity. Results of a national household survey. Br J Psychiatry (2001) 2.01
Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure. Circulation (2000) 2.01
The background, design and use of a short interview to assess social stress and support in research and clinical settings. Soc Sci Med E (1981) 2.01
Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. Gastroenterology (1995) 2.00
Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. J Control Release (2000) 1.96
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nat Genet (2001) 1.95
A phytochrome from the fern Adiantum with features of the putative photoreceptor NPH1. Proc Natl Acad Sci U S A (1998) 1.93
Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia. Cancer Res (1979) 1.93
A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody. Virology (1993) 1.90
Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors. Cancer Res (1983) 1.84
p26 protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts. Virology (1992) 1.84
Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish. Neuron (2001) 1.83
Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. Arch Pathol Lab Med (1998) 1.81
Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups. Proc Natl Acad Sci U S A (1994) 1.81
Isolation of Hfr strains from R+ and ColV2+ strains of Escherichia coli and derivation of an R'lac factor by transduction. J Bacteriol (1973) 1.79
Decrease in culture temperature releases monolayer endothelial cell sheets together with deposited fibronectin matrix from temperature-responsive culture surfaces. J Biomed Mater Res (1999) 1.77
Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Hum Gene Ther (1998) 1.72
Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups. J Gen Virol (1996) 1.72
Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement. J Exp Med (1985) 1.72
Prognostic implications of fibrotic focus (scar) in small peripheral lung cancers. Am J Surg Pathol (1980) 1.72
Mechanical properties of the binary titanium-zirconium alloys and their potential for biomedical materials. J Biomed Mater Res (1995) 1.72
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature (1983) 1.71
Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product. J Virol Methods (1999) 1.70
Mosaic isochromosome 20q found on amniocentesis with normal outcome. Prenat Diagn (1990) 1.70
Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res (1991) 1.70
Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer: a pilot clinical study. Am J Gastroenterol (1999) 1.69
Psychosocial and psychiatric risk factors for suicide. Case-control psychological autopsy study. Br J Psychiatry (2000) 1.69
HCV genotypes in chronic hepatitis C and response to interferon. Lancet (1992) 1.67
The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric Morbidity . Psychol Med (1998) 1.67
Ionic currents through the membrane of the mammalian oocyte and their comparison with those in the tunicate and sea urchin. J Physiol (1977) 1.67
Epidemic of hand, foot and mouth disease associated with enterovirus 71 infection. Intervirology (1978) 1.67
Neurotic disorders and the receipt of psychiatric treatment. Psychol Med (2000) 1.66
Characterization of a putative colonization factor (PCFO166) of enterotoxigenic Escherichia coli of serogroup O166. J Gen Microbiol (1989) 1.65
Development of the polymer micelle carrier system for doxorubicin. J Control Release (2001) 1.64
Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells. Cancer Res (1984) 1.64
Significance of Aspergillus species isolated from respiratory secretions in the diagnosis of invasive pulmonary aspergillosis. J Clin Microbiol (1980) 1.64
Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med (1995) 1.63
Strabismus in Williams syndrome. Am J Ophthalmol (1995) 1.63
Liver transplantation as a treatment for familial amyloidotic polyneuropathy. Ann Intern Med (1994) 1.63
Making psychiatric epidemiology useful: the contribution of epidemiology to government policy. Acta Psychiatr Scand (2001) 1.62
Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas. Int J Oncol (1998) 1.62
Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem (1990) 1.60
Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum (1999) 1.60
Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: comparison with genomes of the other three subtypes. J Gen Virol (1986) 1.59