Published in Nat Cell Biol on March 01, 2015
Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice. Proc Natl Acad Sci U S A (2015) 0.89
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell (2017) 0.88
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis. Cell Stem Cell (2016) 0.88
Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature (2017) 0.79
Dynamic membrane depolarization is an early regulator of ependymoglial cell response to spinal cord injury in axolotl. Dev Biol (2015) 0.75
Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons. Mol Ther (2017) 0.75
New approaches for direct conversion of patient fibroblasts into neural cells. Brain Res (2015) 0.75
Stem Cell-Mediated Regeneration of the Adult Brain. Transfus Med Hemother (2016) 0.75
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2. Nat Commun (2017) 0.75
Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium. PLoS One (2017) 0.75
Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nat Nanotechnol (2017) 0.75
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol (2006) 10.95
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature (2010) 6.85
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat Biotechnol (2008) 6.82
Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature (2012) 6.65
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 6.21
Generation of functional human pancreatic β cells in vitro. Cell (2014) 5.90
Hepatitis C virus replication in mice with chimeric human livers. Nat Med (2001) 5.87
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development (2000) 5.30
Plasticity of adult stem cells. Cell (2004) 5.13
Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A (2011) 4.81
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell (2011) 4.65
Functional screening identifies miRNAs inducing cardiac regeneration. Nature (2012) 4.39
Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32
Generation and regeneration of cells of the liver and pancreas. Science (2008) 4.21
A pericyte origin of spinal cord scar tissue. Science (2011) 4.12
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med (2000) 3.96
In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A (2000) 3.80
Extreme makeover: converting one cell into another. Cell Stem Cell (2008) 3.60
Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol (2014) 3.46
Glial cells generate neurons: the role of the transcription factor Pax6. Nat Neurosci (2002) 3.37
Direct conversion of C. elegans germ cells into specific neuron types. Science (2010) 3.31
Diabetes mellitus and the β cell: the last ten years. Cell (2012) 3.31
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med (2003) 3.26
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol (2014) 3.20
Organogenesis in a dish: modeling development and disease using organoid technologies. Science (2014) 2.98
Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet (2012) 2.75
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol (2004) 2.68
Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol (2010) 2.60
In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat Cell Biol (2013) 2.56
Generation of induced neurons via direct conversion in vivo. Proc Natl Acad Sci U S A (2013) 2.51
The stem cell potential of glia: lessons from reactive gliosis. Nat Rev Neurosci (2011) 2.49
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J Clin Invest (2013) 2.38
Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. J Neurosci (2007) 2.27
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. Cell Stem Cell (2013) 2.26
Experimental conversion of liver to pancreas. Curr Biol (2003) 2.24
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature (2014) 2.19
Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci U S A (2005) 2.09
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol (2013) 2.06
Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell (2009) 2.00
Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci (2013) 1.98
Neural stem cells: generating and regenerating the brain. Neuron (2013) 1.95
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell (2013) 1.77
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell (2012) 1.76
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol (2012) 1.74
Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet (2011) 1.73
Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease. Lancet Neurol (2013) 1.72
Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev (2011) 1.69
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons. Nat Neurosci (2013) 1.64
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci (2013) 1.62
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci (2014) 1.57
Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (2014) 1.52
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science (2014) 1.52
Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol Ther (2007) 1.51
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex. Nat Protoc (2011) 1.49
Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell (2014) 1.47
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell (2013) 1.46
Genes controlling pancreas ontogeny. Int J Dev Biol (2008) 1.45
Rethinking differentiation: stem cells, regeneration, and plasticity. Cell (2014) 1.41
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports (2014) 1.38
In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun (2014) 1.38
Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo. Nat Neurosci (2010) 1.36
Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology (2011) 1.35
Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo. Nat Cell Biol (2013) 1.34
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun (2003) 1.27
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes (2011) 1.26
Remote control of induced dopaminergic neurons in parkinsonian rats. J Clin Invest (2014) 1.23
In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts. Proc Natl Acad Sci U S A (2012) 1.23
Development-inspired reprogramming of the mammalian central nervous system. Science (2014) 1.21
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife (2013) 1.19
Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block. Sci Transl Med (2014) 1.12
Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron (2014) 1.11
Environmental impact on direct neuronal reprogramming in vivo in the adult brain. Nat Commun (2013) 1.11
Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol (2009) 1.10
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci U S A (2013) 1.09
Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. J Neurosci (2013) 1.09
Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat Neurosci (2004) 1.08
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife (2014) 1.08
Removal of Polycomb repressive complex 2 makes C. elegans germ cells susceptible to direct conversion into specific somatic cell types. Cell Rep (2012) 1.07
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy. Mol Ther (2012) 1.07
Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells. Cell Stem Cell (2014) 1.06
De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts. Cell Rep (2014) 1.02
Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell (2012) 1.01
Rewiring the brain with cell transplantation in Parkinson's disease. Trends Neurosci (2011) 1.00
Alpha cells come of age. Trends Endocrinol Metab (2012) 0.98
Developing dopaminergic cell therapy for Parkinson's disease--give up or move forward? Mov Disord (2013) 0.97
Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Ther (2014) 0.97
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci (2014) 0.96
Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res (2013) 0.95
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. Cell Stem Cell (2013) 0.91
Mitosis gives a brief window of opportunity for a change in gene transcription. PLoS Biol (2014) 0.88