Somatic mutations of cell-free circulating DNA detected by next-generation sequencing reflect the genetic changes in both germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphomas at the time of diagnosis.

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Published in Haematologica on March 06, 2015

Authors

Elodie Bohers1, Pierre Julien Viailly1, Sydney Dubois1, Philippe Bertrand1, Catherine Maingonnat1, Sylvain Mareschal1, Philippe Ruminy1, Jean-Michel Picquenot2, Christian Bastard1, Fabienne Desmots3, Thierry Fest3, Karen Leroy4, Hervé Tilly5, Fabrice Jardin6

Author Affiliations

1: INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
2: Department of Pathology, Centre Henri Becquerel, Rouen, France.
3: UMR INSERM U917, CHU Pontchaillou, Rennes, France.
4: INSERM U955, Henri Mondor Hospital, Creteil, France.
5: INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France.
6: INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France fabrice.jardin@chb.unicancer.fr.

Associated clinical trials:

Assessment of the Minimal Residual Disease in DLBCL From Cell-free Circulating DNA by NGS (LymphoSeq) | NCT02339805

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