Familial Hypercholesterolemia: a Review of the Natural History, Diagnosis, and Management.

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Published in Cardiol Ther on March 14, 2015

Authors

Osman Najam1, Kausik K Ray

Author Affiliations

1: Cardiovascular Sciences Research Centre, St George's University, London, UK.

Associated clinical trials:

Niacin Plus Statin to Prevent Vascular Events | NCT00120289

Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE (HPS2-THRIVE) | NCT00461630

IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) | NCT00202878

Durable Effect of PCSK9 Antibody CompARed wiTh placEbo Study (DESCARTES) | NCT01516879

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects -2 (GAUSS-2) | NCT01763905

Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities (TESLA) | NCT01588496

Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2 (RUTHERFORD-2) | NCT01763918

LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2 (LAPLACE-2) | NCT01763866

Monoclonal Antibody Against PCSK9 to Reduce Elevated LDL-C in Subjects Currently Not Receiving Drug Therapy for Easing Lipid Levels-2 (MENDEL-2) | NCT01763827

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