Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMID 25786813)

Published in Neuropathol Appl Neurobiol on May 30, 2015

Authors

Nichola Z Lax1, John Grady1, Alex Laude2, Felix Chan3, Philippa D Hepplewhite1, Grainne Gorman1, Roger G Whittaker3,4, Yi Ng1, Mark O Cunningham3, Doug M Turnbull1

Author Affiliations

1: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
2: Bio-imaging Unit, Newcastle University, Newcastle upon Tyne, UK.
3: Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
4: Department of Clinical Neurophysiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Articles cited by this

Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition. J Neurosci (2006) 5.12

Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem (1990) 4.03

Retinitis pigmentosa, external ophthalmophegia, and complete heart block: unusual syndrome with histologic study in one of two cases. AMA Arch Ophthalmol (1958) 2.91

GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat Neurosci (2013) 2.67

Mitochondrial disease in adults: a scale to monitor progression and treatment. Neurology (2006) 1.87

Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria. Brain (2010) 1.86

Impaired and repaired inhibitory circuits in the epileptic human hippocampus. Trends Neurosci (2005) 1.82

The clinical maze of mitochondrial neurology. Nat Rev Neurol (2013) 1.72

The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons. J Neurosci (2013) 1.59

Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement. Neuropathol Appl Neurobiol (2006) 1.29

Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion. Hum Mol Genet (2008) 1.29

Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy. Ann Neurol (2000) 1.20

Cerebellar ataxia in patients with mitochondrial DNA disease: a molecular clinicopathological study. J Neuropathol Exp Neurol (2012) 1.17

Inhibitory neurons in the human epileptogenic temporal neocortex. An immunocytochemical study. Brain (1996) 1.12

POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection. Brain (2008) 1.10

The psychiatric presentation of mitochondrial disorders in adults. J Neuropsychiatry Clin Neurosci (2012) 1.08

Populations of hippocampal inhibitory neurons express different levels of cytochrome c. Eur J Neurosci (2006) 1.06

Histochemical localization of cytochrome oxidase in the hippocampus: correlation with specific neuronal types and afferent pathways. Neuroscience (1982) 1.05

Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms. Curr Neurovasc Res (2005) 1.04

Sensory neuronopathy in patients harbouring recessive polymerase γ mutations. Brain (2011) 1.03

Highly energized inhibitory interneurons are a central element for information processing in cortical networks. J Cereb Blood Flow Metab (2014) 0.96

Neuropathology in Kearns-Sayre syndrome. Acta Neuropathol (1990) 0.90

Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue. J Neurosci Methods (2014) 0.87

Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons. Brain (2011) 0.86

Molecular pathogenesis of polymerase γ-related neurodegeneration. Ann Neurol (2014) 0.85

Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects. Brain (2012) 0.84

Microangiopathy in the cerebellum of patients with mitochondrial DNA disease. Brain (2012) 0.83

The neuropsychologic deficits of MELAS: evidence of global impairment. Cogn Behav Neurol (2007) 0.82

Loss of myelin-associated glycoprotein in kearns-sayre syndrome. Arch Neurol (2012) 0.81

Focal cognitive impairment in mitochondrial encephalomyopathies: a neuropsychological and neuroimaging study. J Neurol Sci (1999) 0.80

Decreased hippocampal expression of calbindin D28K and cognitive impairment in MELAS. J Neurol Sci (2012) 0.80

Stroke and Stroke-Like Symptoms in Patients with Mutations in the POLG1 Gene. JIMD Rep (2011) 0.78