Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4461396)

Published in J Cardiovasc Pharmacol on June 01, 2015

Authors

Telma M Nakata1, Ryou Tanaka, Rieko Yoshiyuki, Toshiharu Fukayama, Seijiro Goya, Ryuji Fukushima

Author Affiliations

1: Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology (TUAT), Tokyo, Japan.

Articles cited by this

Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr (2010) 13.12

Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr (2003) 11.88

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med (2005) 6.50

Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation (2006) 4.69

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med (2009) 3.96

Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol (2011) 3.69

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol (2009) 3.64

Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation (2008) 3.63

Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr (1997) 3.53

Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J (2004) 3.51

Hormones and hemodynamics in heart failure. N Engl J Med (1999) 3.50

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation (2007) 3.33

Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med (2002) 3.32

Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation (2008) 3.25

The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest (2009) 2.92

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circ Heart Fail (2010) 2.82

Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation (2005) 2.18

Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation (2009) 2.17

Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: a prospective, controlled, blinded, and randomized study. J Vet Intern Med (2007) 2.17

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem (2005) 2.12

Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study. Circulation (2005) 1.79

Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol (2009) 1.78

Reversal of left ventricular hypertrophy in hypertensive patients. A metaanalysis of 109 treatment studies. Am J Hypertens (1992) 1.73

Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels. J Am Coll Cardiol (1995) 1.65

Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest (1992) 1.59

Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med (2000) 1.59

The role of the right ventricle in pulmonary arterial hypertension. Eur Respir Rev (2011) 1.57

Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. Am J Cardiol (1998) 1.57

The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol (2011) 1.54

Right ventricular dysfunction compromises accuracy of echocardiographic diagnosis of pulmonary hypertension in heart failure. J Card Fail (2011) 1.44

Pulmonary arterial hypertension: pathophysiology and anesthetic approach. Anesthesiology (2003) 1.42

Echocardiography in the assessment of right heart function. Eur J Echocardiogr (2008) 1.34

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension. J Pharmacol Exp Ther (1997) 1.29

Serial noninvasive assessment of progressive pulmonary hypertension in a rat model. Am J Physiol Heart Circ Physiol (2002) 1.29

RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart (2014) 1.26

Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension. Am J Cardiol (1985) 1.21

Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. Br J Pharmacol (2002) 1.20

Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest (2005) 1.20

Sequence of echocardiographic changes during development of right ventricular failure in rat. J Am Soc Echocardiogr (2006) 1.16

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors. Am J Physiol (1994) 1.14

Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone. Circ Res (1988) 1.13

Differential expression of PDE5 in failing and nonfailing human myocardium. Circ Heart Fail (2011) 1.11

A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model. Int J Cardiovasc Imaging (2010) 1.11

Phosphodiesterase inhibitors for the treatment of pulmonary hypertension. Eur Respir J (2008) 1.08

Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil (SG-75). J Cardiovasc Pharmacol (1983) 1.08

Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. Am J Physiol Heart Circ Physiol (2006) 1.05

Alterations in cardiac beta-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs. Eur J Pharmacol (1987) 1.04

Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: an overview. J Cardiovasc Pharmacol (1987) 1.01

Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ Res (1991) 0.99

Echocardiographic assessment of right heart hemodynamic parameters. J Am Soc Echocardiogr (2007) 0.95

The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev (2013) 0.93

Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes. Cardiovasc Res (2003) 0.93

Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension. PLoS One (2012) 0.90

The value of tools to assess pulmonary arterial hypertension. Eur Respir Rev (2011) 0.90

Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction. Am J Physiol Heart Circ Physiol (2005) 0.89

Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats. J Cardiovasc Pharmacol (2005) 0.89

Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale. Cardiovasc Res (1997) 0.88

New insights in the treatment strategy for pulmonary arterial hypertension. Cardiovasc Drugs Ther (2006) 0.86

Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations. Naunyn Schmiedebergs Arch Pharmacol (1991) 0.86

Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure: the effects of pimobendan on chronic heart failure study (EPOCH study). Circ J (2002) 0.85

Evaluation of pimobendan and N-terminal probrain natriuretic peptide in the treatment of pulmonary hypertension secondary to degenerative mitral valve disease in dogs. J Vet Intern Med (2009) 0.85

New echocardiographic prognostic factors for mortality in pulmonary arterial hypertension. Eur J Echocardiogr (2010) 0.85

Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy. Cardiovasc Toxicol (2005) 0.85

Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs. Br J Pharmacol (1996) 0.84

Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension. J Thromb Haemost (2006) 0.83

Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension. J Cardiovasc Pharmacol (1998) 0.83

The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension. J Heart Lung Transplant (1999) 0.83

Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. Cardiovasc Toxicol (2005) 0.82

Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension. PLoS One (2012) 0.82

Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. Br J Anaesth (2006) 0.82

Pulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors. Chest (2004) 0.80

Pimobendane (UD-CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross-over and double-blind study with two different doses. Br J Clin Pharmacol (1988) 0.80

Low-dose systemic phosphodiesterase III inhibitor pimobendan combined with prostacyclin therapy in a patient with severe primary pulmonary hypertension. Cardiovasc Drugs Ther (2003) 0.79

Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats. J Cardiovasc Pharmacol Ther (2012) 0.79

Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation. Jpn J Pharmacol (2000) 0.79

Right ventricular diastolic performance: compliance characteristics with focus on pulmonary hypertension, right ventricular hypertrophy, and calcium channel blockade. Cathet Cardiovasc Diagn (1998) 0.78

Hypoxic vasoconstriction of rat main pulmonary artery: role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition. J Cardiovasc Pharmacol (2001) 0.77

Pericardial effusion in pulmonary arterial hypertension. Pulm Circ (2013) 0.76

Articles by these authors

Existence of feline morbillivirus infection in Japanese cat populations. Arch Virol (2013) 1.12

Small-diameter silk vascular grafts (3 mm diameter) with a double-raschel knitted silk tube coated with silk fibroin sponge. Adv Healthc Mater (2012) 0.84

Surgical correction of subvalvular aortic stenosis using cardiopulmonary bypass in a dog. J Vet Med Sci (2004) 0.80

Successful surgical correction of supravalvular pulmonary stenosis under beating heart using a cardiopulmonary bypass system in a dog. J Vet Med Sci (2009) 0.78

Effects of beta-blocker on left ventricular remodeling in rats with volume overload cardiac failure. J Vet Med Sci (2008) 0.78

Effects of enfonidipine hydrochloride in dogs with experimental supraventricular tachyarrhythmia. J Vet Med Sci (2010) 0.78

Effect of long-term administration of a prostacyclin analogue (beraprost sodium) on myocardial fibrosis in Dahl rats. J Vet Med Sci (2007) 0.77

Histological study of right ventricle-pulmonary artery valved conduit implantation (RPVC) in dogs with pulmonic stenosis. J Vet Med Sci (2009) 0.77

Long-term clinical evaluation of mitral valve replacement with porcine bioprosthetic valves in dogs. J Vet Med Sci (2008) 0.76

Cardiovascular effects of right ventricle-pulmonary artery valved conduit implantation in experimental pulmonic stenosis. J Vet Med Sci (2009) 0.76

Cardiac remodeling and angiotensin II-forming enzyme activity of the left ventricle in hamsters with chronic pressure overload induced by ascending aortic stenosis. J Vet Med Sci (2006) 0.76

Evaluation of changes in left ventricular myocardial function observed in canine myocardial dysfunction model using a two-dimensional tissue tracking technique. J Vet Sci (2013) 0.75

Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension. J Vet Med Sci (2016) 0.75

Comparative effects of amlodipine and benazepril on left atrial pressure in dogs with experimentally-induced mitral valve regurgitation. BMC Vet Res (2012) 0.75

Effects of postural change on transesophageal echocardiography views and parameters in healthy dogs. J Vet Med Sci (2016) 0.75

Quantitative PCR detection of feline morbillivirus in cat urine samples. J Vet Med Sci (2015) 0.75

Epidemiological and clinical features of the endomyocardial form of restrictive cardiomyopathy in cats: a review of 41 cases. J Vet Med Sci (2016) 0.75

Preventive effect of sildenafil on right ventricular function in rats with monocrotaline-induced pulmonary arterial hypertension. Exp Anim (2016) 0.75

A long term comparison between Denacol EX-313-treated bovine jugular vein graft and ultrafine polyester fiber graft for reconstruction of tight ventricular outflow tract in dogs. J Vet Med Sci (2003) 0.75

Megaesophagus was complicated with Billroth I gastroduodenostomy in a cat. J Vet Med Sci (2005) 0.75

The effect of intermittent administration of sustained release isosorbide dinitrate (sr-ISDN) in rats with volume overload heart. J Vet Med Sci (2006) 0.75

Effects of dopamine infusion on cardiac and renal blood flows in dogs. J Vet Med Sci (2002) 0.75

Epidemiological and morphological studies of double-chambered right ventricle in dogs. J Vet Med Sci (2011) 0.75

Omental herniation through the esophageal hiatus in a cat. J Vet Med Sci (2002) 0.75

Extreme tetralogy of Fallot in a dog. J Vet Med Sci (2013) 0.75

Chronic effect of transrectal split-focus ultrasonic ablation on canine prostatic tissue. J Vet Med Sci (2006) 0.75

Effect of Angiotensin II Type 1 receptor blocker on cardiac angiotensin-converting enzyme and chymase-like activities, and cardiac fibrosis in cardiomyopathic hamsters. J Vet Med Sci (2006) 0.75

Effect of intermittent administration of sustained release isosorbide dinitrate (sr-ISDN) in rats with pressure-overload heart. J Vet Med Sci (2006) 0.75

Implantation of permanent transvenous endocardial pacemaker in a dog with atrioventricular block. J Vet Med Sci (2003) 0.75

An experimental study of apico-aortic valved conduit (AAVC) for surgical treatment of aortic stenosis in dogs. J Vet Med Sci (2005) 0.75

Percutaneous transcatheter coil embolization of a ventricular septal defect in a dog. J Am Vet Med Assoc (2005) 0.75

Surgical correction of pulmonic stenosis using transventricular pulmonic dilation valvuloplasty (Brock) in a dog. J Vet Med Sci (2007) 0.75

Short-term performance of mitral valve replacement with porcine bioprosthetic valves in dogs. J Vet Med Sci (2007) 0.75

Comparative evaluation of calcium-sensitizing agents, pimobendan and SCH00013, on the myocardial function of canine pacing-induced model of heart failure. J Pharmacol Sci (2014) 0.75

Comparison of right atrium incision and right ventricular outflow incision for surgical repair of membranous ventricular septal defect using cardiopulmonary bypass in dogs. Vet Surg (2006) 0.75

Comparison of extracapillary and endocapillary blood flow oxygenators for open heart surgery in dogs: efficiency of gas exchange and platelet conservation. J Vet Med Sci (2003) 0.75

Cor triatriatum sinister with incomplete atrioventricular septal defect in a cat. J Feline Med Surg (2011) 0.75

Echocardiographic estimation of left atrial pressure in beagle dogs with experimentally-induced mitral valve regurgitation. J Vet Med Sci (2011) 0.75

Hydrodynamic characteristics of porcine aortic valves cross-linked with glutaraldehyde and polyepoxy compounds. ASAIO J (2009) 0.75

Surgical correction of a partial atrioventricular septal defect with a ventricular septal defect in a dog. J Am Anim Hosp Assoc (2005) 0.75