Published in Front Neurosci on March 13, 2015
Extensive alterations of blood metabolites in pediatric cerebral malaria. PLoS One (2017) 0.75
The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19
Structure and function of the blood-brain barrier. Neurobiol Dis (2009) 7.64
Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell Mol Neurobiol (2005) 2.58
The ready isomerization of bilirubin IX- in aqueous solution. Biochem J (1972) 2.50
The influence of cytokines on the integrity of the blood-brain barrier in vitro. J Neuroimmunol (1996) 2.34
Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group. N Engl J Med (1994) 2.31
Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb Pathog (2001) 2.15
Bile-acid-induced cell injury and protection. World J Gastroenterol (2009) 2.06
New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. Pediatr Neurol (2013) 2.01
Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons. Hepatology (2002) 1.96
IL-6 increases endothelial permeability in vitro. Endocrinology (1992) 1.73
Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches. Brain Res Rev (2010) 1.67
Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid. J Hepatol (2001) 1.54
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthritis Cartilage (2006) 1.46
Bile acids: regulation of apoptosis by ursodeoxycholic acid. J Lipid Res (2009) 1.36
Blood brain barrier in hypoxic-ischemic conditions. Curr Neurovasc Res (2008) 1.35
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A (2002) 1.29
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proc Natl Acad Sci U S A (2003) 1.27
Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'. J Hepatol (2001) 1.24
The blood-brain barrier in neurodegenerative disease: a rhetorical perspective. J Neurochem (2009) 1.20
Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice. Clin Chem (2009) 1.17
Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem (2012) 1.16
Reticulophagy and ribophagy: regulated degradation of protein production factories. Int J Cell Biol (2012) 1.16
Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies. Fluids Barriers CNS (2013) 1.15
Circulating endothelial cells: a novel marker of endothelial damage. Clin Chim Acta (2006) 1.13
Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem (2008) 1.11
Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis (2004) 1.09
Pentosan polysulfate protects brain endothelial cells against bacterial lipopolysaccharide-induced damages. Neurochem Int (2006) 1.06
Binding of bilirubin with lipid. A possible mechanism of its toxic reactions in mitochondria. J Biol Chem (1970) 1.06
Bile acid structure-activity relationship: evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC. J Lipid Res (1990) 1.05
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli. J Cell Physiol (2010) 1.03
Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin. J Neurochem (2006) 1.02
MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes. Eur J Neurosci (2007) 1.01
Factors affecting the binding of bilirubin to serum albumins: validation and application of the peroxidase method. Pediatr Res (2006) 0.98
The blood-brain barrier and bilirubin encephalopathy. Cell Mol Neurobiol (2000) 0.98
Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells. PLoS One (2012) 0.98
Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. Cell Transplant (2002) 0.97
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. Front Pharmacol (2012) 0.96
Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. Mol Med (2004) 0.96
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. Cell Mol Life Sci (2009) 0.96
Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation. Neurobiol Dis (2010) 0.95
Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin. Pediatr Res (2002) 0.93
Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. Biochem Biophys Res Commun (2001) 0.92
Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid. Neurotoxicology (2007) 0.92
Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management. Eur J Clin Invest (2000) 0.91
Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal. Eur J Obstet Gynecol Reprod Biol (1998) 0.91
Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem (2009) 0.90
Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology (1990) 0.90
ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin. Neuromolecular Med (2012) 0.90
Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization. Mol Med (2000) 0.90
Dissociated primary nerve cell cultures as models for assessment of neurotoxicity. Toxicol Lett (2005) 0.89
Ultrastructure of the Gunn rat substantia nigra I. Cytoplasmic changes. Acta Neuropathol (1976) 0.89
A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes. Brain Res (2004) 0.89
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria. J Hepatol (2002) 0.88
Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model. J Neurosci Methods (2014) 0.88
Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state. Acta Neuropathol (2006) 0.88
The effect of bile salts on the permeability and ultrastructure of the perfused, energy-depleted, rat blood-brain barrier. J Cereb Blood Flow Metab (1991) 0.87
Bilirubin produces apoptosis in cultured bovine brain endothelial cells. Brain Res (2002) 0.87
Endothelial Cells Derived from the Blood-Brain Barrier and Islets of Langerhans Differ in their Response to the Effects of Bilirubin on Oxidative Stress Under Hyperglycemic Conditions. Front Pharmacol (2012) 0.87
Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. Neuropharmacology (2012) 0.86
Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors. Mol Neurobiol (2013) 0.86
Safety, tolerability, and cerebrospinal fluid penetration of ursodeoxycholic Acid in patients with amyotrophic lateral sclerosis. Clin Neuropharmacol (2010) 0.86
Understanding neonatal jaundice: a perspective on causation. Pediatr Neonatol (2010) 0.86
Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial. J Korean Med Sci (2012) 0.86
Serum bilirubin and bilirubin/albumin ratio as predictors of bilirubin encephalopathy. Pediatrics (2014) 0.86
Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats. Biochem Biophys Res Commun (1996) 0.85
Intestinal absorption and biliary secretion of ursodeoxycholic acid and its taurine conjugate. Eur J Clin Invest (2002) 0.85
Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes. Clin Sci (Lond) (2002) 0.84
Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model. J Ocul Pharmacol Ther (2010) 0.84
Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin. J Neuropathol Exp Neurol (2007) 0.83
Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining. Front Cell Neurosci (2012) 0.83
Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity. Curr Neurovasc Res (2011) 0.82
Ursodeoxycholic acid decreases bilirubin-induced osteoblast apoptosis. Eur J Clin Invest (2014) 0.82
Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiting vasculogenic progenitor cells. Stem Cells (2015) 0.81
Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. Eur J Pharmacol (2004) 0.81
Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver. BMC Res Notes (2010) 0.80
Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus. J Child Neurol (2011) 0.80
Subcellular localization of bilirubin in rat brain after in vivo i.v. administration of [3H]bilirubin. Pediatr Res (2001) 0.79
Structural change of ribosomes during apoptosis: degradation and externalization of ribosomal proteins in doxorubicin-treated Jurkat cells. J Biochem (2002) 0.79
Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin. Neurochem Res (2001) 0.79
Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype. Neuroscience (2001) 0.78
Acute effects of short-chain alkylglycerols on blood-brain barrier properties of cultured brain endothelial cells. Br J Pharmacol (2013) 0.77
Anti-angiogenic activity of ursodeoxycholic acid and its derivatives. Cancer Lett (1997) 0.77
Microglia centered pathogenesis in ALS: insights in cell interconnectivity. Front Cell Neurosci (2014) 1.00