Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

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Published in Nat Commun on March 31, 2015

Authors

Masahiro Miyake1, Kenji Yamashiro2, Yasuharu Tabara3, Kenji Suda2, Satoshi Morooka2, Hideo Nakanishi2, Chiea-Chuen Khor4, Peng Chen5, Fan Qiao5, Isao Nakata1, Yumiko Akagi-Kurashige1, Norimoto Gotoh3, Akitaka Tsujikawa2, Akira Meguro6, Sentaro Kusuhara7, Ozen Polasek8, Caroline Hayward9, Alan F Wright9, Harry Campbell10, Andrea J Richardson11, Maria Schache11, Masaki Takeuchi12, David A Mackey13, Alex W Hewitt11, Gabriel Cuellar14, Yi Shi15, Luling Huang15, Zhenglin Yang16, Kim Hung Leung17, Patrick Y P Kao18, Maurice K H Yap18, Shea Ping Yip17, Muka Moriyama19, Kyoko Ohno-Matsui19, Nobuhisa Mizuki6, Stuart MacGregor14, Veronique Vitart9, Tin Aung20, Seang-Mei Saw21, E-Shyong Tai22, Tien Yin Wong23, Ching-Yu Cheng24, Paul N Baird11, Ryo Yamada3, Fumihiko Matsuda3, Nagahama Study Group, Nagahisa Yoshimura2

Author Affiliations

1: 1] Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan [2] Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
2: Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
3: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
4: 1] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Department of Pediatrics, National University of Singapore, Singapore 119077, Singapore [4] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
5: Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
6: Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan.
7: Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 6570013, Japan.
8: Faculty of Medicine, University of Split, Split 21000, Croatia.
9: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK.
10: Centre for Population Health Sciences, Medical School, Teviot, Edinburgh EH8 9AG, UK.
11: Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
12: 1] Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan [2] Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
13: 1] Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia [2] Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia.
14: Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
15: Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
16: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China [2] School of Medicine, University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China [3] Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan 610072, China.
17: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
18: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
19: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 1130034, Japan.
20: 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
21: 1] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
22: 1] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore [2] Department of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Duke-NUS Graduate Medical School, Singapore 169857, Singapore.
23: 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 1130034, Japan [3] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
24: 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [3] Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

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