Thymoquinone protects end organs from abdominal aorta ischemia/reperfusion injury in a rat model.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 4389520)

Published in Rev Bras Cir Cardiovasc on April 11, 2015

Authors

Mehmet Salih Aydin1, Aydemir Kocarslan1, Sezen Kocarslan2, Ahmet Kucuk3, İrfan Eser3, Hatice Sezen4, Evren Buyukfirat5, Abdussemet Hazar1

Author Affiliations

1: Department of Cardiovascular Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
2: Department of Pathology, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
3: Department of Thoracic Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
4: Department of Biochemistry, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
5: Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.

Articles cited by this

A new automated colorimetric method for measuring total oxidant status. Clin Biochem (2005) 5.59

A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem (2004) 4.00

The morphology of "acute tubular necrosis" in man: analysis of 57 renal biopsies and a comparison with the glycerol model. Medicine (Baltimore) (1979) 2.58

Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction. World J Surg (2001) 2.14

Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol (2011) 1.76

Studies on the antimicrobial activity of Nigella sativa seed (black cumin). J Ethnopharmacol (1991) 1.50

Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med (2009) 1.46

Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol (2003) 1.39

Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res (2000) 1.37

Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct (2002) 1.28

Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis (2005) 1.24

Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther (2007) 1.23

The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol (1993) 1.08

Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur J Pharmacol (2006) 1.07

The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review. Saudi J Kidney Dis Transpl (2009) 1.06

Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol (2002) 1.04

Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res (2007) 1.00

Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol (2007) 1.00

The inflammatory response to vascular surgery-associated ischaemia and reperfusion in man: effect on postoperative pulmonary function. Eur J Vasc Endovasc Surg (1997) 0.99

Limb remote ischemic preconditioning for intestinal and pulmonary protection during elective open infrarenal abdominal aortic aneurysm repair: a randomized controlled trial. Anesthesiology (2013) 0.98

Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury. Drug Discov Ther (2009) 0.96

Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. J Biochem Mol Toxicol (2010) 0.95

Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs. Pharmacol Rep (2010) 0.93

The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury. Pak J Pharm Sci (2013) 0.92

Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol (2008) 0.92

Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model. Int Immunopharmacol (2011) 0.91

Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats. Toxicology (2012) 0.90

Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia-reperfusion in rats. J Pharm Pharmacol (2011) 0.88

Thymoquinone in the clinical treatment of cancer: Fact or fiction? Pharmacogn Rev (2013) 0.87

Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats. Hum Exp Toxicol (2012) 0.85

Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys. Ren Fail (2010) 0.84

Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver. Food Chem Toxicol (2010) 0.84

Evaluation of the effect of thymoquinone treatment on wound healing in a rat burn model. J Burn Care Res (2013) 0.84

Protective effect of thymoquinone in experimental testicular torsion. Urol Int (2010) 0.82

Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats. Inflammopharmacology (2012) 0.80

Circulating neutrophil priming and systemic inflammation in limb ischaemia-reperfusion injury. Int Angiol (2001) 0.79

Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis--a dose response study in rats. Indian J Exp Biol (2013) 0.79

Antioxidative and anti-inflammatory effect of thymoquinone in an acute Pseudomonas prostatitis rat model. Urol Int (2013) 0.79

Plasmatic vasopressin in patients undergoing conventional infra-renal abdominal aorta aneurysm repair. Rev Bras Cir Cardiovasc (2011) 0.78

Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells. Exp Ther Med (2010) 0.77