Imaging systemic inflammatory networks in ischemic heart disease.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 25881940)

Published in J Am Coll Cardiol on April 21, 2015

Authors

Matthias Nahrendorf1, Stefan Frantz2, Filip K Swirski3, Willem J M Mulder4, Gwendalyn Randolph5, Georg Ertl6, Vasilis Ntziachristos7, Jan J Piek8, Erik S Stroes9, Markus Schwaiger10, Douglas L Mann11, Zahi A Fayad12

Author Affiliations

1: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: mnahrendorf@partners.org.
2: Comprehensive Heart Failure Center, Universitätsklinikum Würzburg, Würzburg, Germany; Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle, Halle (Saale), Germany.
3: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
4: Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
5: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
6: Comprehensive Heart Failure Center, Universitätsklinikum Würzburg, Würzburg, Germany; Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Germany.
7: Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany.
8: Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
9: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
10: Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
11: Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
12: Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York.

Articles cited by this

Inflammation in atherosclerosis. Nature (2002) 28.92

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51

Imaging in the era of molecular oncology. Nature (2008) 11.10

Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47

Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science (2007) 9.54

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest (2007) 9.09

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest (2007) 8.65

Macrophages in the pathogenesis of atherosclerosis. Cell (2011) 7.78

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature (2008) 6.61

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47

Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol (2009) 5.28

Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial. Lancet (2011) 4.67

Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48

Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med (2006) 4.28

Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14

Imaging of atherosclerotic cardiovascular disease. Nature (2008) 4.14

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J (2011) 3.93

In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol (2006) 3.91

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med (2006) 3.65

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity (2014) 3.54

Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J Am Coll Cardiol (2009) 3.44

Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med (2006) 3.38

Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction:a possible role for left ventricular remodeling. J Am Coll Cardiol (2002) 3.27

Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study. J Am Coll Cardiol (2013) 3.25

Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science (2013) 3.22

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol (2011) 3.04

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med (2012) 2.92

Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol (2010) 2.90

Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood (2004) 2.52

Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell (2013) 2.49

Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation (2011) 2.45

PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol (2012) 2.39

Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans. JACC Cardiovasc Imaging (2015) 2.02

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med (2012) 2.02

Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir. Eur Heart J (2013) 1.83

Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res (2014) 1.78

An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile. PLoS One (2012) 1.76

Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia. J Am Coll Cardiol (2014) 1.64

Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity (2012) 1.63

Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol (2008) 1.60

Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis. Am Heart J (2013) 1.60

Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction. J Cell Mol Med (2009) 1.58

Characterizing the inflammatory tissue response to acute myocardial infarction by clinical multimodality noninvasive imaging. Circ Cardiovasc Imaging (2014) 1.58

Real-time in vivo imaging of the beating mouse heart at microscopic resolution. Nat Commun (2012) 1.58

Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest (2012) 1.57

In vivo imaging of enhanced leukocyte accumulation in atherosclerotic lesions in humans. J Am Coll Cardiol (2014) 1.56

Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res (2014) 1.52

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nat Med (2013) 1.43

Ultrasmall superparamagnetic particles of iron oxide in patients with acute myocardial infarction: early clinical experience. Circ Cardiovasc Imaging (2012) 1.32

Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation. Circ Res (2014) 1.30

Intravital 2-photon imaging of leukocyte trafficking in beating heart. J Clin Invest (2012) 1.28

Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts. Circ Res (2013) 1.26

Molecular imaging of coronary atherosclerosis and myocardial infarction: considerations for the bench and perspectives for the clinic. Circ Res (2011) 1.25

Imaging and nanomedicine in inflammatory atherosclerosis. Sci Transl Med (2014) 1.23

In vivo bioluminescence for tracking cell fate and function. Am J Physiol Heart Circ Physiol (2011) 1.20

Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging. Circ Cardiovasc Imaging (2014) 1.15

68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors. EJNMMI Res (2012) 1.14

Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow. Eur Heart J (2011) 1.09

Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis. Circ Res (2014) 1.07

Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach. Eur Heart J (2012) 1.05

2-deoxy-2-[18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis. Nat Med (2014) 1.02

Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res (2014) 1.00

Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation (2014) 0.99

Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated phospholipase A2 inhibitor, on arterial inflammation as assessed with 18F-fluorodeoxyglucose-positron emission tomography imaging. J Am Coll Cardiol (2013) 0.88

Caught in the act: in vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarction. Biochem Biophys Res Commun (2006) 0.87

Will 18F-sodium fluoride PET-CT imaging be the magic bullet for identifying vulnerable coronary atherosclerotic plaques? Curr Cardiol Rep (2014) 0.85

Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation. J Nucl Med (2014) 0.84

Imaging plaques to predict and better manage patients with acute coronary events. Circ Res (2014) 0.82

Cells and iron oxide nanoparticles on the move: magnetic resonance imaging of monocyte homing and myocardial inflammation in patients with ST-elevation myocardial infarction. Circ Cardiovasc Imaging (2012) 0.82

Fluorine MR Imaging of Inflammation in Atherosclerotic Plaque in Vivo. Radiology (2014) 0.81

Imaging of angiogenesis in cardiology. Eur J Nucl Med Mol Imaging (2007) 0.76

Articles by these authors

The prognostic value of bleeding academic research consortium (BARC)-defined bleeding complications in ST-segment elevation myocardial infarction: a comparison with the TIMI (Thrombolysis In Myocardial Infarction), GUSTO (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries), and ISTH (International Society on Thrombosis and Haemostasis) bleeding classifications. J Am Coll Cardiol (2014) 1.58

In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol (2013) 1.41

High-risk plaque features can be detected in non-stenotic carotid plaques of patients with ischaemic stroke classified as cryptogenic using combined (18)F-FDG PET/MR imaging. Eur J Nucl Med Mol Imaging (2015) 0.83

Evaluation of 18F-fluoride PET/MR and PET/CT in patients with foot pain of unclear cause. J Nucl Med (2015) 0.78

Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma. J Biophotonics (2016) 0.77

Multiparametric human hepatocellular carcinoma characterization and therapy response evaluation by hyperpolarized (13) C MRSI. NMR Biomed (2016) 0.77

Hyperpolarized (13)C Diffusion MRS of Co-Polarized Pyruvate and Fumarate to Measure Lactate Export and Necrosis. J Cancer (2017) 0.75

2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia. Eur Heart J (2017) 0.75

Unraveling Vascular Inflammation: From Immunology to Imaging. J Am Coll Cardiol (2017) 0.75