Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice.

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🔗 View Article (PMC 4395934)

Published in Part Fibre Toxicol on March 07, 2015

Authors

Yang Sun1, Feng Guo2, Zhen Zou3, Chenggang Li4, Xiaoxu Hong5,6,7, Yan Zhao8, Chenxuan Wang9, Hongliang Wang10, Haolin Liu11, Peng Yang12, Zongsheng Han13, Kangtai Liu14, Keiji Kuba15, Bin Song16, Jinming Gao17, Ziyao Mo18, Dangsheng Li19, Bo Li20, Qihan Li21, Nanshan Zhong22, Chen Wang23, Josef M Penninger24, Chengyu Jiang25,26,27

Author Affiliations

1: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. biosuny@gmail.com.
2: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. guofengsd@gmail.com.
3: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. zouzhenat9t@gmail.com.
4: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. lichenggang1981@gmail.com.
5: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. Hongxx2000@sina.com.
6: Institute of Medical Biology, Chinese Academy of Medical Sciences, No. 379, Jiaoling Road, Kunming, Yunnan, 650118, China. Hongxx2000@sina.com.
7: Chinese Pharmacopeia Commission, No. 11 Building Fahuananli Chongwen District, Beijing, 100060, China. Hongxx2000@sina.com.
8: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. zhaoyanray@126.com.
9: National Center for Nanoscience and Technology, Beijing, 100190, China. wangcx@nanoctr.cn.
10: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. whl2468@aliyun.com.
11: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. LiuH2@njhealth.org.
12: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. yangp459@126.com.
13: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. hanzongsheng.com@163.com.
14: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. liukangtai_001@163.com.
15: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse3, A-1030, Vienna, Austria. kuba.mtt@mri.tmd.ac.jp.
16: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. songbinbj@gmail.com.
17: Center for Translational Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, PR China. gaojm@pumch.cn.
18: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, Guangdong, 510120, China. moziyao@163.net.
19: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. dsli@sibs.ac.cn.
20: National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Hongda Middle Street A8, Beijing Economic and Technological Development Area, Beijing, 100176, China. libo@nicpbp.org.cn.
21: Institute of Medical Biology, Chinese Academy of Medical Sciences, No. 379, Jiaoling Road, Kunming, Yunnan, 650118, China. liqihan@imbcams.com.cn.
22: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, Guangdong, 510120, China. nanshan@vip.163.com.
23: National Center for Nanoscience and Technology, Beijing, 100190, China. wangch@nanoctr.cn.
24: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse3, A-1030, Vienna, Austria. josef.penninger@imba.oeaw.ac.at.
25: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China. jiang@pumc.edu.cn.
26: Center for Translational Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, PR China. jiang@pumc.edu.cn.
27: State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610000, China. jiang@pumc.edu.cn.

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