Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.

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🔗 View Article (PMID 25894828)

Published in Nat Med on April 20, 2015

Authors

Razvan Cristescu1, Jeeyun Lee2, Michael Nebozhyn1, Kyoung-Mee Kim3, Jason C Ting4, Swee Seong Wong4, Jiangang Liu4, Yong Gang Yue4, Jian Wang4, Kun Yu4, Xiang S Ye4, In-Gu Do3, Shawn Liu5, Lara Gong5, Jake Fu6, Jason Gang Jin6, Min Gew Choi7, Tae Sung Sohn7, Joon Ho Lee7, Jae Moon Bae7, Seung Tae Kim2, Se Hoon Park2, Insuk Sohn8, Sin-Ho Jung8, Patrick Tan9, Ronghua Chen1, James Hardwick1, Won Ki Kang2, Mark Ayers1, Dai Hongyue1, Christoph Reinhard4, Andrey Loboda1, Sung Kim7, Amit Aggarwal4

Author Affiliations

1: Department of Genetics and Pharmacogenomics, Merck Research Laboratories, Merck Sharpe &Dohme, Boston, Massachusetts, USA.
2: Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
3: Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
4: Lilly Research Labs, Eli Lilly &Co, Indianapolis, Indiana, USA.
5: BGI Tech Solutions, Hong Kong, China.
6: Shanghai Biocorp, Shanghai, China.
7: Department of Surgery, Gastric Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
8: Biostatistics and Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
9: 1] Program in Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore. [2] Genome Institute of Singapore, Singapore.

Associated clinical trials:

Prospective Evaluation and Molecular Profiling in People With Gastric Tumors | NCT03027427

A Validation Study of Relationships Among Genomic Gene Expression Profile, Prognosis and Prediction of Adjuvant Chemotherapy Benefit With Capecitabine and Oxaliplatin in Gastric Cancer Stage II and III (6th AJCC) Patients After D2 Surgery (CLASSIC) | NCT03403296

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