Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.

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Published in Am Heart J on February 12, 2015

Authors

Alex Pitcher1, Jonathan Emberson2, Ronald V Lacro3, Lynn A Sleeper4, Mario Stylianou5, Lynn Mahony6, Gail D Pearson5, Maarten Groenink7, Barbara J Mulder7, Aeilko H Zwinderman7, Julie De Backer8, Anne M De Paepe9, Eloisa Arbustini10, Guliz Erdem11, Xu Yu Jin12, Marcus D Flather13, Michael J Mullen14, Anne H Child15, Alberto Forteza16, Arturo Evangelista17, Hsin-Hui Chiu18, Mei-Hwan Wu19, George Sandor20, Ami B Bhatt21, Mark A Creager22, Richard B Devereux23, Bart Loeys24, J Colin Forfar12, Stefan Neubauer25, Hugh Watkins26, Catherine Boileau27, Guillaume Jondeau28, Harry C Dietz29, Colin Baigent2

Author Affiliations

1: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address: alex.pitcher@cardiov.ox.ac.uk.
2: Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford, UK.
3: Children's Hospital Boston and Harvard Medical School, Boston, MA.
4: New England Research Institutes, Watertown, MA.
5: National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
6: University of Texas Southwestern Medical Center, Dallas, TX.
7: Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
8: Center for Medical Genetics and Department of Cardiology, University Hospital Ghent, Ghent, Belgium.
9: Center for Medical Genetics, University Hospital Ghent, Ghent, Belgium.
10: Centre for Inherited Cardiovascular Diseases, IRCCS Foundation, San Matteo Hospital, Pavia, Italy.
11: Clinical Trials and Evaluation Unit, Royal Brompton & Harefield NHS Trust, London, UK.
12: John Radcliffe Hospital, Oxford, UK.
13: Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
14: UCL Institute of Cardiovascular Science, The Heart Hospital, London, UK.
15: Department of Cardiac and Vascular Sciences, St George's Hospital, University of London, London, UK.
16: Hospital Universitario 12 de Octubre, Madrid, Spain.
17: Marfan Sydrome Unit, Department of Cardiology, Hospital Vall d'Hebron, Barcelona, Spain.
18: Department of Pediatrics and Adult Congenital Heart Center, Taipei Medical University Hospital, Taipei, Taiwan.
19: Department of Pediatrics and Adult Congenital Heart Center, National Taiwan University Hospital, Taipei, Taiwan.
20: Children's Heart Centre, British Columbia's Children's Hospital, Vancouver, British Columbia, Canada.
21: Massachusetts General Hospital, Boston, MA.
22: Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
23: Weill Cornell Medical College and New York-Presbyterian Hospital, New York, NY.
24: Center for Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
25: Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
26: Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
27: Inserm LVTS U1148, Departement de Génétique, Hôpital Xavier Bichat-Claude Bernard, Paris, France.
28: Centre National de Référence pour le syndrome de Marfan et apparentés, INSERM LVTS U1148, Service de Cardiologie, AP-HP Hôpital Bichat, Paris, France.
29: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, and the Howard Hughes Medical Institute, Baltimore, MD.

Associated clinical trials:

Losartan Versus Atenolol for the Treatment of Marfan Syndrome | NCT00593710

Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome | NCT00723801

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