Matrix-Immobilized BMP-2 on Microcontact Printed Fibronectin as an in vitro Tool to Study BMP-Mediated Signaling and Cell Migration.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4426815)

Published in Front Bioeng Biotechnol on May 11, 2015

Authors

Kristin Hauff1, Chiara Zambarda2, Miriam Dietrich3, Maria Halbig2, Anna Luise Grab3, Rebecca Medda2, Elisabetta Ada Cavalcanti-Adam2

Author Affiliations

1: Department of Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg , Heidelberg , Germany ; Applied Chemistry, University of Reutlingen , Reutlingen , Germany.
2: Department of Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg , Heidelberg , Germany ; Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems , Stuttgart , Germany.
3: Department of Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg , Heidelberg , Germany.

Articles cited by this

Soft lithography in biology and biochemistry. Annu Rev Biomed Eng (2001) 11.36

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J (2011) 10.70

The extracellular matrix: not just pretty fibrils. Science (2009) 8.52

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93

One-dimensional topography underlies three-dimensional fibrillar cell migration. J Cell Biol (2009) 5.07

Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99

Cell interactions with three-dimensional matrices. Curr Opin Cell Biol (2002) 4.34

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev (2005) 3.97

Cell migration in tumors. Curr Opin Cell Biol (2005) 3.88

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane. Am J Pathol (1988) 3.72

Microengineering of cellular interactions. Annu Rev Biomed Eng (2000) 3.31

Growth factors in the extracellular matrix. FASEB J (1997) 2.71

The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem (2001) 2.59

Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev (2009) 2.57

Bone morphogenetic proteins: a critical review. Cell Signal (2010) 2.54

Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circ Res (2006) 2.08

Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol (2006) 1.99

Emerging modes of collective cell migration induced by geometrical constraints. Proc Natl Acad Sci U S A (2012) 1.69

BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev (2009) 1.68

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J (2010) 1.62

Matrix control of transforming growth factor-β function. J Biochem (2012) 1.39

Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle- and bone-like subpopulations. Stem Cells (2007) 1.37

Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration. Biomaterials (2010) 1.31

Microcontact printing of novel co-polymers in combination with proteins for cell-biological applications. Biomaterials (2003) 1.25

Substrate topography induces a crossover from 2D to 3D behavior in fibroblast migration. Biophys J (2009) 1.22

The motility of normal and cancer cells in response to the combined influence of the substrate rigidity and anisotropic microstructure. Biomaterials (2008) 1.18

BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity. J Cell Sci (2008) 1.18

Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression. Exp Cell Res (2011) 1.16

Presentation of BMP-2 from a soft biopolymeric film unveils its activity on cell adhesion and migration. Adv Mater (2011) 1.06

Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin beta1 into lipid rafts. Exp Cell Res (2006) 1.05

Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol (2010) 1.02

Potentiation of platelet-derived growth factor receptor-β signaling mediated by integrin-associated MFG-E8. Arterioscler Thromb Vasc Biol (2011) 1.02

Fibronectin at select sites binds multiple growth factors and enhances their activity: expansion of the collaborative ECM-GF paradigm. J Invest Dermatol (2013) 1.01

Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes Its ligand-dependent action on cell migration. J Biol Chem (2003) 1.00

Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions. J Biol Chem (2012) 0.99

Precise control of cell adhesion by combination of surface chemistry and soft lithography. Adv Healthc Mater (2012) 0.95

The effects of carrier nature and pH on rhBMP-2-induced ectopic bone formation. J Control Release (2010) 0.93

Initiation of BMP2 signaling in domains on the plasma membrane. J Cell Physiol (2012) 0.91

Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Nano Lett (2015) 0.87

Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation. Acta Biomater (2011) 0.86

Spatial patterning of BMP-2 and BMP-7 on biopolymeric films and the guidance of muscle cell fate. Biomaterials (2014) 0.86

Universal chemical gradient platforms using poly(methyl methacrylate) based on the biotin-streptavidin interaction for biological applications. Langmuir (2010) 0.86

BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex. BMC Biol (2014) 0.82

Continuous bone morphogenetic protein-2 gradients for concentration effect studies on C2C12 osteogenic fate. Nanomedicine (2013) 0.81

Design, fabrication and in vitro evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering. J Tissue Eng Regen Med (2012) 0.80

Guidance of mesenchymal stem cells on fibronectin structured hydrogel films. PLoS One (2014) 0.77