Active immunization with Tocilizumab mimotopes induces specific immune responses.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4450830)

Published in BMC Biotechnol on June 02, 2015

Authors

Lin Yang1, Rui Xing2, Changhong Li3, Yuan Liu4, Lin Sun5, Xiangyuan Liu6, Yongfu Wang7

Author Affiliations

1: Department of Rheumatology and Immunology, Peking University Third Hospital, No.49, HuaYuan (North) Road, Beijing, 100191, People's Republic of China. hellmirage@hotmail.com.
2: Department of Rheumatology and Immunology, Peking University Third Hospital, No.49, HuaYuan (North) Road, Beijing, 100191, People's Republic of China. hedxxr1987@163.com.
3: Department of Rheumatology and Immunology, Peking University Third Hospital, No.49, HuaYuan (North) Road, Beijing, 100191, People's Republic of China. lichanghong@bjumu.edu.cn.
4: Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, No.41, LinYin Road, Baotou, 014010, People's Republic of China. liuyuanem@163.com.
5: Department of Rheumatology and Immunology, Peking University Third Hospital, No.49, HuaYuan (North) Road, Beijing, 100191, People's Republic of China. slin@163.com.
6: Department of Rheumatology and Immunology, Peking University Third Hospital, No.49, HuaYuan (North) Road, Beijing, 100191, People's Republic of China. liuxiangyuan2014@hotmail.com.
7: Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, No.41, LinYin Road, Baotou, 014010, People's Republic of China. wyf5168@hotmail.com.

Articles cited by this

Evolving concepts of rheumatoid arthritis. Nature (2003) 14.31

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol (2007) 13.70

Peptides on phage: a vast library of peptides for identifying ligands. Proc Natl Acad Sci U S A (1990) 6.34

Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood (2005) 4.29

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity (1997) 4.19

Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med (2012) 4.15

Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol (2006) 4.10

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet (2008) 3.80

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (2003) 2.87

Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood (2000) 2.31

Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone (2003) 1.93

Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res (1993) 1.77

Therapeutic targeting of the interleukin-6 receptor. Annu Rev Pharmacol Toxicol (2011) 1.76

Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene (1993) 1.47

Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries. Gene (1993) 1.26

Interleukin-6: from identification of the cytokine to development of targeted treatments. Joint Bone Spine (2010) 1.06

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain. Proc Natl Acad Sci U S A (2002) 1.04

A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy. Semin Immunol (2014) 1.00

Tocilizumab in the treatment of rheumatoid arthritis and beyond. Drug Des Devel Ther (2014) 0.97

Immunological tolerance using synthetic peptides--basic mechanisms and clinical application. Curr Mol Med (2006) 0.93