Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges.

PubWeight™: 0.76‹?›

🔗 View Article (PMC 4452053)

Published in Mol Cell Ther on July 28, 2014

Authors

Stuart I Jenkins1, Humphrey H P Yiu2, Matthew J Rosseinsky3, Divya M Chari1

Author Affiliations

1: Cellular and Neural Engineering Group, Institute for Science and Technology in Medicine Keele University, Stoke-on-Trent, Staffordshire ST5 5BG UK.
2: School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS UK.
3: Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD UK.

Associated clinical trials:

Safety Study of GRNOPC1 in Spinal Cord Injury | NCT01217008

Articles cited by this

Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci (2005) 5.66

Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science (1999) 5.13

Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol (2001) 4.84

Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol (2001) 4.54

Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology (2003) 3.71

Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell (2008) 3.04

Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev (2009) 2.57

A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res (2003) 2.55

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood (2003) 2.50

Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci U S A (1999) 2.42

Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application. Quant Imaging Med Surg (2011) 2.07

Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature (1993) 2.00

Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials (2007) 1.97

Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. Biomaterials (2003) 1.96

Embryonic stem cell pioneer Geron exits field, cuts losses. Nat Biotechnol (2012) 1.88

Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage (2002) 1.82

Multiple sclerosis. Annu Rev Med (2002) 1.80

Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci (2005) 1.75

Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging. Biomaterials (2008) 1.70

Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury. Stem Cells (2010) 1.63

Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J Neurosci (2010) 1.59

Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. J Neurosci (2010) 1.46

Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomaterials (2010) 1.23

Optimized labeling of bone marrow mesenchymal cells with superparamagnetic iron oxide nanoparticles and in vivo visualization by magnetic resonance imaging. J Nanobiotechnology (2011) 1.19

Combination of transfection agents and magnetic resonance contrast agents for cellular imaging: relationship between relaxivities, electrostatic forces, and chemical composition. Magn Reson Med (2003) 1.17

The translational biology of remyelination: past, present, and future. Glia (2014) 1.16

MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord. Exp Neurol (2006) 1.15

Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality. Small (2010) 1.12

Long-term tracking of cells using inorganic nanoparticles as contrast agents: are we there yet? Chem Soc Rev (2012) 1.06

Oligodendrocyte-protection and remyelination post-spinal cord injuries: a review. Prog Neurobiol (2012) 1.05

Focused magnetic stem cell targeting to the retina using superparamagnetic iron oxide nanoparticles. Cell Transplant (2012) 1.04

Multifunctional Magnetic Nanoparticles for Medical Imaging Applications. J Mater Chem (2009) 1.03

Mesoporous silica nanoparticles enhance MTT formazan exocytosis in HeLa cells and astrocytes. Toxicol In Vitro (2009) 1.02

Enhancement of magnetic nanoparticle-mediated gene transfer to astrocytes by 'magnetofection': effects of static and oscillating fields. Nanomedicine (Lond) (2010) 1.02

Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain. Neuroreport (1999) 1.02

Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury. Int J Nanomedicine (2012) 1.01

Ferumoxytol for the treatment of iron deficiency. Expert Rev Hematol (2011) 0.96

GRNOPC1: the world's first embryonic stem cell-derived therapy. Interview with Jane Lebkowski. Regen Med (2011) 0.96

Remyelination in multiple sclerosis. Int Rev Neurobiol (2007) 0.94

Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies. ACS Nano (2011) 0.94

Human embryonic stem cell therapy in the post-Geron era. Regen Med (2012) 0.93

Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies. Biotechnol Adv (2013) 0.93

Magnetic resonance imaging of cells in experimental disease models. Prog Nucl Magn Reson Spectrosc (2009) 0.92

From precursors to myelinating oligodendrocytes: contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain. Neuroscience (2014) 0.91

Oligodendroglial progenitor cell therapy limits central neurological deficits in mice with metachromatic leukodystrophy. J Neurosci (2006) 0.91

Promoting remyelination in multiple sclerosis-recent advances. Drugs (2013) 0.91

Stem cell-based therapy for spinal cord injury. Cell Transplant (2012) 0.90

Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurones, astroglial and microglial cells. J Neurochem (2002) 0.90

The tragedy of translation: the case of "first use" in human embryonic stem cell research. Cell Stem Cell (2011) 0.88

Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia. Brain Res Bull (2002) 0.86

Cellular magnetic resonance with iron oxide nanoparticles: long-term persistence of SPIO signal in the CNS after transplanted cell death. Nanomedicine (Lond) (2014) 0.86

Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia. BMC Neurosci (2012) 0.85

Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond) (2012) 0.84

Therapeutic effects with magnetic targeting of bone marrow stromal cells in a rat spinal cord injury model. Spine (Phila Pa 1976) (2011) 0.84

In search of human oligodendroglia for myelin repair. Neurosci Lett (2009) 0.84

Engineered nanoparticles. How brain friendly is this new guest? Prog Neurobiol (2014) 0.84

Fe3O4-PEI-RITC magnetic nanoparticles with imaging and gene transfer capability: development of a tool for neural cell transplantation therapies. Pharm Res (2011) 0.82

Neural stem cells as a potential source of oligodendrocytes for myelin repair. J Neurol Sci (2005) 0.82

Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis. Mult Scler (2013) 0.81

What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury? BMC Neurol (2011) 0.81

Transplanted transgenically marked oligodendrocytes survive, migrate and myelinate in the normal mouse brain as they do in the shiverer mouse brain. Eur J Neurosci (1994) 0.81

Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment. J Immunol Res (2014) 0.80

Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus. Eur J Neurosci (2007) 0.78

Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells. Neurochem Res (2010) 0.78

Searching for oligodendrocyte precursors for cell replacement therapies. Acta Neurobiol Exp (Wars) (2011) 0.78

Treatment with iron oxide nanoparticles induces ferritin synthesis but not oxidative stress in oligodendroglial cells. Acta Biomater (2011) 0.77

Remyelination strategies: new advancements toward a regenerative treatment in multiple sclerosis. Curr Neurol Neurosci Rep (2006) 0.77

Uptake of fluorescent iron oxide nanoparticles by oligodendroglial OLN-93 cells. Neurochem Res (2013) 0.76