Androgen pathway resistance in prostate cancer and therapeutic implications.

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Published in Expert Opin Pharmacother on June 12, 2015

Authors

Benjamin L Maughan1, Emmanuel S Antonarakis

Author Affiliations

1: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center , 1650 Orleans St. CRB1 186, Baltimore, MD USA.

Associated clinical trials:

Phase 3 Study of Immunotherapy to Treat Advanced Prostate Cancer | NCT01057810

Abiraterone Acetate and Prednisone With or Without Veliparib in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT01576172

A Study to Determine Safety and Tolerability of Enzalutamide (MDV3100) in Combination With Abiraterone Acetate in Bone Metastatic Castration-Resistant Prostate Cancer Patients | NCT01650194

Study of GDC-0068 Or GDC-0980 With Abiraterone Acetate Versus Abiraterone Acetate in Patients With Castration-Resistant Prostate Cancer Previously Treated With Docetaxel Chemotherapy | NCT01485861

A 2 Part, Phase 2 Trial of Galeterone in the Treatment of Castration Resistant Prostate Cancer (ARMOR2) | NCT01709734

Enzalutamide With or Without Abiraterone and Prednisone in Treating Patients With Castration-Resistant Metastatic Prostate Cancer | NCT01949337

A Dose-Finding Study of OTX105/MK-8628, a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003) | NCT02259114

Combining Ipilimumab With Abiraterone Acetate Plus Prednisone in Chemotherapy and Immunotherapy-naïve Patients With Progressive Metastatic Castration-resistant Prostate Cancer | NCT01688492

A Study of HSP90 Inhibitor AT13387 Alone or in Combination With Abiraterone Acetate | NCT01685268

Enzalutamide With or Without Vaccine Therapy for Advanced Prostate Cancer | NCT01867333

Phase Ib of Abiraterone Acetate Plus BEZ235 or BKM120 in Castration-resistant Prostate Cancer (CRPC) Patients | NCT01634061

PROSTVAC®-VF/TRICOM™ Vaccine for the Treatment of Metastatic Prostate Cancer After Failing Hormone Therapy | NCT00078585

Abiraterone Acetate and Prednisone With or Without Dasatinib in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT01685125

XL-184+Abiraterone in Post-Chemo CRPC | NCT01574937

A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer (SPARTAN) | NCT01946204

AMG 386 and Abiraterone for Advanced Prostate Cancer | NCT01553188

Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms (ERA 223) | NCT02043678

A Phase II Trial of MLN8237 in Patients With Metastatic Castrate Resistant and Neuroendocrine Prostate Cancer | NCT01799278

Alisertib, Abiraterone Acetate and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer | NCT01848067

Efficacy and Safety Study of BAY1841788 (ODM-201) in Men With High-risk Non-metastatic Castration-resistant Prostate Cancer (ARAMIS) (ARAMIS) | NCT02200614

CYT107 After Vaccine Treatment (Provenge) in Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT01881867

Ph II Study to Evaluate Olaparib With Abiraterone in Treating Metastatic Castration Resistant Prostate Cancer | NCT01972217

A Study to Evaluate Oral VT-464 in Patients With Castration-Resistant Prostate Cancer | NCT02012920

Sequencing Abiraterone and Enzalutamide in mCRPC | NCT02125357

A Study of Oral CFG920 in Patients With Castration Resistant Prostate Cancer | NCT01647789

A Safety Study of Abiraterone Acetate Administered in Combination With Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (mCRPC) | NCT01400555

Pembrolizumab in Treating Patients With Metastatic Castration Resistant Prostate Cancer Previously Treated With Enzalutamide | NCT02312557

Phase III Study of DCVAC Added to Standard Chemotherapy for Men With Metastatic Castration Resistant Prostate Cancer (VIABLE) | NCT02111577

Cabazitaxel Versus the Switch to Alternative AR Targeted Therapy Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Primary Resistant Patients to Abiraterone or Enzalutamide (PRIMCAB) | NCT02379390

RE-sensitizing With Supraphysiologic Testosterone to Overcome REsistant (The RESTORE Study) (Restore) | NCT02090114

A Study of Enzalutamide and LY3023414 in Men With Prostate Cancer | NCT02407054

Dose-finding Study of GSK2636771 When Administered in Combination With Enzalutamide in Male Subjects With Metastatic Castration-Resistant Prostate Cancer | NCT02215096

Oral VT-464 in Patients With Castration-Resistant Prostate Cancer Previously Treated With Enzalutamide | NCT02130700

A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer | NCT02123758

ARN 509 Plus Everolimus in Men With Progressive Metastatic Castration-Resistant Prostate Cancer After Treatment With Abiraterone Acetate | NCT02106507

BI836845 Plus Enzalutamide in Castrate Resistant Prostate Cancer (CRPC) | NCT02204072

Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men With Metastatic Castration Resistant Prostate Cancer (mCRPC) (PCF) | NCT02269982

Crizotinib in Combination With Enzalutamide in Metastatic Castration-resistant Prostate Cancer | NCT02207504

Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates Enzalutamide Resistance (Transformer) | NCT02286921

Multicenter Trial of Abiraterone Acetate With or Without Cabazitaxel in Treatment of Metastatic Castration Resistant Prostate Cancer | NCT02218606

Dose-Finding Study of Afuresertib Administered in Combination With Either Enzalutamide or Aibraterone | NCT02380313

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