Published in Trends Mol Med on June 09, 2015
Prefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats. Neuroscience (2016) 0.80
Frontal Gamma-Aminobutyric Acid Concentrations Are Associated With Cognitive Performance in Older Adults. Biol Psychiatry Cogn Neurosci Neuroimaging (2017) 0.80
Implications of GABAergic Neurotransmission in Alzheimer's Disease. Front Aging Neurosci (2016) 0.79
Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats. Psychopharmacology (Berl) (2016) 0.78
Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex. Neurobiol Aging (2016) 0.77
GABA predicts visual intelligence. Neurosci Lett (2016) 0.76
Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice. PLoS One (2016) 0.76
Selective vulnerabilities and biomarkers in neurocognitive aging. F1000Res (2017) 0.75
NR2A-containing NMDARs in the prefrontal cortex are required for working memory and associated with age-related cognitive decline. J Neurosci (2016) 0.75
Adolescent Cannabinoid Use and Cognition; Unexpected Results from a Rat Model of Cannabinoid Self-Administration. Neuropsychopharmacology (2016) 0.75
Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs. Evid Based Complement Alternat Med (2017) 0.75
Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4. Biosci Rep (2016) 0.75
Cognitive deficits caused by a disease-mutation in the α3 Na(+)/K(+)-ATPase isoform. Sci Rep (2016) 0.75
A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer's disease. Alzheimers Res Ther (2016) 0.75
Chronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons. BMC Genomics (2017) 0.75
The space where aging acts: focus on the GABAergic synapse. Aging Cell (2017) 0.75
Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human aging. Neurobiol Aging (2017) 0.75
Endocrine changes at midlife and their influence on circuits important for learning and memory: Ovarian hormones rule them all. Exp Gerontol (2016) 0.75
Attenuated Activity Across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex. J Neurosci (2017) 0.75
Place navigation impaired in rats with hippocampal lesions. Nature (1982) 15.79
Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci (2005) 9.25
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science (2008) 9.24
Cellular basis of working memory. Neuron (1995) 8.22
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron (2007) 6.60
GABAergic cell subtypes and their synaptic connections in rat frontal cortex. Cereb Cortex (1997) 6.24
Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron (2004) 5.44
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci (1992) 5.02
Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol (2004) 4.89
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci U S A (2003) 4.33
Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav Neurosci (1993) 4.33
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature (2001) 4.32
Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J Neurosci (2006) 4.14
A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron (2000) 3.98
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology (2005) 3.90
Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell (2007) 3.60
Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks. Curr Opin Neurobiol (1995) 3.47
Do rats have a prefrontal cortex? Behav Brain Res (2003) 3.38
Neuronal basis of age-related working memory decline. Nature (2011) 3.15
Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci (1993) 3.11
Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron (2012) 2.89
Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med (2010) 2.77
The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci (2012) 2.76
Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex. J Neurosci (1995) 2.76
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci (2004) 2.73
Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron (2011) 2.67
Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron (2006) 2.53
Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J Neurosci (2000) 2.51
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci U S A (1996) 2.46
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Neuron (2003) 2.41
Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron (2012) 2.40
Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus (2010) 2.39
Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging (1993) 2.38
Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci (2008) 2.37
The use of animal models to study the effects of aging on cognition. Annu Rev Psychol (1997) 2.32
The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci (2003) 2.18
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol (2007) 2.13
Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron (2012) 1.99
Basal cortisol levels and cognitive deficits in human aging. J Neurosci (1994) 1.97
Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc Natl Acad Sci U S A (2004) 1.95
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci (2010) 1.93
Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc Natl Acad Sci U S A (2011) 1.88
Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex. Neuron (2005) 1.87
Rodent models of prefrontal cortical function. Trends Neurosci (2002) 1.84
Age-associated alterations of hippocampal place cells are subregion specific. J Neurosci (2005) 1.82
Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice. J Neurophysiol (2006) 1.74
Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol Aging (1996) 1.60
An analysis of rat prefrontal cortex in mediating executive function. Neurobiol Learn Mem (2011) 1.59
Inhibitory CA1-CA3-hilar region feedback in the hippocampus. Science (1994) 1.58
Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. Eur J Neurosci (2003) 1.56
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. Neural Plast (2011) 1.51
Synapses are lost during aging in the primate prefrontal cortex. Neuroscience (2007) 1.50
Evidence for task-dependent memory dysfunction in the aged monkey. J Neurosci (1989) 1.49
Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm Behav (2005) 1.48
Effects of age on virtual environment place navigation and allocentric cognitive mapping. Behav Neurosci (2002) 1.47
The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. J Neurosci (1988) 1.45
Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia. Biol Psychiatry (2010) 1.40
Lifelong corticosterone level determines age-related decline in neurogenesis and memory. Neurobiol Aging (2005) 1.39
Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology (2009) 1.39
GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer. J Neurosci (2001) 1.37
Place cell rigidity correlates with impaired spatial learning in aged rats. Neurobiol Aging (2002) 1.28
Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network. Neuropsychopharmacology (2010) 1.27
Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task. Behav Brain Res (2006) 1.27
Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiol Aging (2007) 1.27
A review of functional brain imaging correlates of successful cognitive aging. Biol Psychiatry (2011) 1.26
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One (2012) 1.24
Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain. Brain Res (1999) 1.23
Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex. Neuroscience (2004) 1.21
GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism. Annu Rev Pharmacol Toxicol (2013) 1.20
Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiol Aging (1991) 1.20
Protein kinase A as a therapeutic target for memory disorders: rationale and challenges. Trends Mol Med (2005) 1.20
Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci (2004) 1.17
Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degeneration. J Neurochem (2004) 1.14
Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Learn Mem (2006) 1.14
Extrahippocampal contributions to age differences in human spatial navigation. Cereb Cortex (2006) 1.13
Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Neurobiol Aging (2009) 1.12
Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited. Ther Adv Neurol Disord (2008) 1.12
Characterizing cognitive aging of spatial and contextual memory in animal models. Front Aging Neurosci (2012) 1.12
GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus. Neuropharmacology (2005) 1.11
SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol (2004) 1.10
Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. Neuropharmacology (2012) 1.10
Pharmacological enhancement of memory and executive functioning in laboratory animals. Neuropsychopharmacology (2010) 1.10
Characterizing cognitive aging of working memory and executive function in animal models. Front Aging Neurosci (2012) 1.09
Hypothalamic-pituitary-adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long-Evans rats. Eur J Neurosci (2001) 1.08
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects. J Neurochem (2001) 1.04
Hilar interneuron vulnerability distinguishes aged rats with memory impairment. J Comp Neurol (2013) 1.04
Phosphodiesterase inhibitors for cognitive enhancement. Curr Pharm Des (2005) 1.02
A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Physiol (2013) 1.02
Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives. Front Cell Neurosci (2014) 1.01
Characterizing cognitive aging in humans with links to animal models. Front Aging Neurosci (2012) 1.01
GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. J Neurophysiol (2008) 0.99
Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging (1991) 0.98
GABAB receptor-dependent modulation of network activity in the rat prefrontal cortex in vitro. Eur J Neurosci (2010) 0.98
Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus. Neuroscience (2006) 0.98
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. J Neurosci (2014) 0.98
Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex. J Comp Neurol (2012) 0.97
Chemistry and pharmacology of GABAB receptor ligands. Adv Pharmacol (2010) 0.97
Preservation of prefrontal cortical volume in behaviorally characterized aged macaque monkeys. Exp Neurol (1999) 0.97
Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr) (2011) 0.97
Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release. J Neural Transm (Vienna) (2008) 0.93