Published in Nat Struct Mol Biol on June 22, 2015
Fatty acylation of Wnt proteins. Nat Chem Biol (2016) 0.87
Evolution of moth sex pheromone composition by a single amino acid substitution in a fatty acid desaturase. Proc Natl Acad Sci U S A (2015) 0.80
Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla. J Lipid Res (2015) 0.78
The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase. J Biol Chem (2015) 0.78
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc Natl Acad Sci U S A (2017) 0.78
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat Chem Biol (2016) 0.76
Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases. J Lipid Res (2015) 0.75
Determination of Substrate Preferences for Desaturases and Elongases for Production of Docosahexaenoic Acid from Oleic Acid in Engineered Canola. Lipids (2017) 0.75
A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool. Chem Commun (Camb) (2016) 0.75
Classification and substrate head-group specificity of membrane fatty acid desaturases. Comput Struct Biotechnol J (2016) 0.75
Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach. Int J Mol Sci (2017) 0.75
Characterization of Stearoyl-CoA Desaturases from a Psychrophilic Antarctic Copepod, Tigriopus kingsejongensis. Mar Biotechnol (NY) (2016) 0.75
Structural basis for catalysis at the membrane-water interface. Biochim Biophys Acta (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Bioinformatics (2009) 31.84
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol (2011) 28.61
Resolution of phase ambiguity in macromolecular crystallography. Methods Enzymol (1985) 11.92
Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Biochemistry (1994) 4.65
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab (2005) 3.47
Three-dimensional structure of the free radical protein of ribonucleotide reductase. Nature (1990) 3.24
Rational protein crystallization by mutational surface engineering. Structure (2004) 2.87
Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins. EMBO J (1996) 2.84
Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. J Biol Chem (1976) 2.77
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res (2002) 2.28
Correlating structure with function in bacterial multicomponent monooxygenases and related diiron proteins. Acc Chem Res (2006) 1.93
Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res (2007) 1.81
Desaturases: emerging models for understanding functional diversification of diiron-containing enzymes. J Biol Chem (2009) 1.57
Structural basis of biological N2O generation by bacterial nitric oxide reductase. Science (2010) 1.44
Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol delta7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype. Plant Physiol (2004) 1.19
Azide and acetate complexes plus two iron-depleted crystal structures of the di-iron enzyme delta9 stearoyl-acyl carrier protein desaturase. Implications for oxygen activation and catalytic intermediates. J Biol Chem (2003) 1.17
Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev (2005) 1.15
Membrane topology of mouse stearoyl-CoA desaturase 1. J Biol Chem (2005) 1.14
Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia (2008) 1.12
The crystal structure of the ivy Delta4-16:0-ACP desaturase reveals structural details of the oxidized active site and potential determinants of regioselectivity. J Biol Chem (2007) 1.04
A multifunctional acyl-acyl carrier protein desaturase from Hedera helix L. (English ivy) can synthesize 16- and 18-carbon monoene and diene products. J Biol Chem (2005) 0.97
Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus. Nat Struct Mol Biol (2012) 0.94
Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis. Cancers (Basel) (2011) 0.94
Structure and mechanism of the diiron benzoyl-coenzyme A epoxidase BoxB. J Biol Chem (2011) 0.85
Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. J Med Chem (2013) 0.83
Stearoyl-CoA desaturase inhibitors: update on patented compounds. Expert Opin Ther Pat (2009) 0.82
An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009 - 2013). Expert Opin Ther Pat (2013) 0.77