Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 4473327)

Published in Am J Cancer Res on March 15, 2015

Authors

David J Monsma1, David M Cherba2, Emily E Eugster3, Dawna L Dylewski4, Paula T Davidson4, Chelsea A Peterson5, Andrew S Borgman2, Mary E Winn2, Karl J Dykema2, Craig P Webb6, Jeffrey P MacKeigan7, Nicholas S Duesbery8, Brian J Nickoloff9, Noel R Monks10

Author Affiliations

1: Vivarium and Transgenics Core, Van Andel Research Institute Grand Rapids, Michigan, USA.
2: Bioinformatics and Biostatistics Core, Van Andel Research Institute Grand Rapids, Michigan, USA.
3: Pathology and Biorepository Core, Van Andel Research Institute Grand Rapids, Michigan, USA.
4: Center for Translational Medicine, Van Andel Research Institute Grand Rapids, Michigan, USA.
5: College of Human Medicine, Michigan State University Grand Rapids, Michigan, USA.
6: NuMedi Palo Alto, California, USA.
7: Laboratory of Systems Biology, Van Andel Research Institute Grand Rapids, Michigan, USA.
8: Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute Grand Rapids, Michigan, USA.
9: Center for Translational Medicine, Van Andel Research Institute Grand Rapids, Michigan, USA ; College of Human Medicine, Michigan State University Grand Rapids, Michigan, USA.
10: Center for Translational Medicine, Van Andel Research Institute Grand Rapids, Michigan, USA ; Current address: Medimmune, One MedImmune Way Gaithersburg, MD, 20878, USA.

Articles cited by this

Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med (2011) 45.46

Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med (2010) 36.57

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature (2010) 18.69

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 16.12

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature (2010) 14.62

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet (2012) 13.89

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature (2011) 10.77

Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med (2011) 5.82

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun (2012) 4.94

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature (2013) 4.90

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov (2013) 4.39

The implications of clonal genome evolution for cancer medicine. N Engl J Med (2013) 2.78

MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Cancer Discov (2013) 2.61

Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. J Clin Oncol (2013) 2.51

Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma. PLoS One (2012) 2.40

Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers. Clin Cancer Res (2010) 2.31

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther (2012) 2.21

Vemurafenib. Nat Rev Drug Discov (2011) 1.68

Successful rechallenge in two patients with BRAF-V600-mutant melanoma who experienced previous progression during treatment with a selective BRAF inhibitor. Melanoma Res (2012) 1.62

Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohistochemical and molecular testing. PLoS One (2013) 1.34

Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression. Clin Cancer Res (2013) 1.25

Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine. Mol Cancer Ther (2012) 1.21

Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer. Cancer Chemother Pharmacol (2011) 1.20

Major therapeutic developments and current challenges in advanced melanoma. Br J Dermatol (2014) 1.07

Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue. J Transl Med (2012) 1.07

Vemurafenib in patients with BRAF V600E mutation-positive advanced melanoma. Clin Ther (2012) 1.07

SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. J Biol Chem (2012) 1.01

Meeting report: The future of preclinical mouse models in melanoma treatment is now. Pigment Cell Melanoma Res (2013) 0.89

Treating advanced melanoma: current insights and opportunities. Cancer Manag Res (2014) 0.89

Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis (2012) 0.87

Melanoma genotypes and phenotypes get personal. Lab Invest (2013) 0.81

Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft. PLoS One (2014) 0.79