Published in J Mol Genet Med on May 01, 2015
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (1980) 40.02
The calpain system. Physiol Rev (2003) 9.95
Changes in diabetes-related complications in the United States, 1990-2010. N Engl J Med (2014) 8.73
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. Prostaglandins (1976) 4.54
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J Biol Chem (1977) 3.02
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A (1992) 2.48
Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annu Rev Med (2010) 2.11
Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. Mol Cell Biol (2004) 2.08
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood (2011) 1.77
The IDF Diabetes Atlas: providing evidence, raising awareness and promoting action. Diabetes Res Clin Pract (2009) 1.58
Cell biology of endothelial cells. Hum Pathol (1987) 1.54
Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab (2013) 1.51
Hyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via μ-calpain activation. Diabetes (2014) 1.51
Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains. J Biol Chem (2005) 1.44
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res (2008) 1.26
Calpains play a role in insulin secretion and action. Diabetes (2001) 1.25
Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats. Hypertension (2001) 1.23
Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res (2009) 1.20
An evolving new paradigm: endothelial cells--conditional innate immune cells. J Hematol Oncol (2013) 1.17
Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain. Cardiovasc Res (2008) 1.14
Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC. Am J Physiol Heart Circ Physiol (2006) 1.13
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. Circulation (2007) 1.13
A novel role for calpains in the endothelial dysfunction of hyperglycemia. FASEB J (2003) 1.11
Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle. Exp Physiol (2007) 1.09
m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2010) 1.07
Endothelial dysfunction in diabetes: multiple targets for treatment. Pflugers Arch (2010) 1.07
Calpain system regulates muscle mass and glucose transporter GLUT4 turnover. J Biol Chem (2004) 1.04
The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes (2005) 1.02
Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain. Diabetes (2007) 1.02
Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase. J Cell Mol Med (2008) 0.99
Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care (1998) 0.98
Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes? Can J Physiol Pharmacol (2005) 0.95
Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction--a novel mechanism for maintaining vascular function. J Hematol Oncol (2014) 0.95
A proenzyme of cyclic nucleotide-independent protein kinase and its activation by calcium-dependent neutral protease from rat liver. Biochem Biophys Res Commun (1977) 0.95
Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. Arterioscler Thromb Vasc Biol (2010) 0.92
Calpain 3 gene expression in skeletal muscle is associated with body fat content and measures of insulin resistance. Int J Obes Relat Metab Disord (2002) 0.91
Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. J Biol Chem (2011) 0.91
Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes. Cardiovasc Diabetol (2014) 0.90
A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling. Circ Res (2011) 0.90
Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. Am J Physiol Cell Physiol (2007) 0.89
Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice. J Pharmacol Exp Ther (2009) 0.89
Effects of autolysis on properties of mu- and m-calpain. Biochim Biophys Acta (2004) 0.88
Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells. Am J Physiol (1998) 0.86
Hyperhomocysteinemia and Endothelial Dysfunction. Curr Hypertens Rev (2009) 0.85
Site-specific proteolysis of cyclooxygenase-2: a putative step in inflammatory prostaglandin E(2) biosynthesis. J Cell Biochem (2007) 0.85
Calpain inhibition and insulin action in cultured human muscle cells. Mol Genet Metab (2005) 0.85
Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha. Mol Genet Metab (2009) 0.83
The calpain inhibitor, A-705253, corrects penile nitrergic nerve dysfunction in diabetic mice. Eur J Pharmacol (2006) 0.83
Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell migration and proliferation. Mol Cell Biochem (2006) 0.82
Vasoconstrictor role of cyclooxygenase-1-mediated prostacyclin synthesis in non-insulin-dependent diabetic mice induced by high-fat diet and streptozotocin. Am J Physiol Heart Circ Physiol (2014) 0.82
m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions. Cardiovasc Res (2009) 0.82
Calpains: a physiological regulator of the endothelial barrier? Am J Physiol Heart Circ Physiol (2005) 0.81
Calpain and atherosclerosis. J Atheroscler Thromb (2012) 0.80
Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes. PLoS One (2009) 0.79
Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. Am J Physiol Cell Physiol (2009) 0.79
Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats. Expert Opin Ther Targets (2009) 0.78
Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells. J Inflamm (Lond) (2009) 0.78
Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. Fundam Clin Pharmacol (2011) 0.75