Published in Mol Pharmacol on July 01, 2015
A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res (2016) 1.42
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems. Pharmacol Rev (2016) 1.02
Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist. Pharmacol Res Perspect (2016) 0.75
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations. Eur J Pharmacol (2016) 0.75
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Operational models of pharmacological agonism. Proc R Soc Lond B Biol Sci (1983) 6.89
Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov (2010) 5.76
Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science (1995) 5.74
ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett (1994) 3.78
Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat Rev Drug Discov (2012) 3.30
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature (2012) 2.96
Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43
Multiple ligand-specific conformations of the β2-adrenergic receptor. Nat Chem Biol (2011) 2.23
A simple method for quantifying functional selectivity and agonist bias. ACS Chem Neurosci (2011) 1.93
The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacol Rev (2001) 1.86
Orphanin FQ/nociceptin blocks acquisition of morphine place preference. Brain Res (1999) 1.32
Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins. J Biol Chem (2011) 1.30
An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol (2014) 1.30
Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy. Mol Pharmacol (2013) 1.19
Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem (2013) 1.17
The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). J Recept Signal Transduct Res (2002) 1.17
Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol (2014) 1.15
Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates. J Pharmacol Exp Ther (2012) 1.07
Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol (2002) 1.07
Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus. J Neurosci (2008) 1.03
The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J Pharmacol Exp Ther (2008) 1.01
Biased agonism as a mechanism for differential signaling by chemokine receptors. J Biol Chem (2013) 1.00
Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors. J Biol Chem (2012) 0.99
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine. Eur J Pharmacol (2007) 0.97
Ligand-regulated internalization of the opioid receptor-like 1: a confocal study. Endocrinology (2004) 0.96
A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol (2014) 0.93
The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine. Neuropharmacology (2007) 0.90
Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor. Nat Chem Biol (2013) 0.87
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I. Bioorg Med Chem Lett (2013) 0.87
Functional selectivity of nociceptin/orphanin FQ peptide receptor partial agonists on cardiovascular and renal function. J Pharmacol Exp Ther (2005) 0.83
Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol (2014) 0.81
Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling. J Biol Chem (2012) 0.81
Functional selectivity at GPCRs: new opportunities in psychiatric drug discovery. Neuropsychopharmacology (2014) 0.81
Agonist-regulated internalization and desensitization of the human nociceptin receptor expressed in CHO cells. Curr Drug Targets (2007) 0.81
Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J Pharmacol Sci (2008) 0.80
NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience (2013) 0.80
C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. Elife (2015) 0.80
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun (2017) 0.75
Structural basis of arrestin-3 activation and signaling. Nat Commun (2017) 0.75