The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.

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Published in Ann Rheum Dis on July 02, 2015

Authors

Tatsuya Atsumi1, Kazuhiko Yamamoto2, Tsutomu Takeuchi3, Hisashi Yamanaka4, Naoki Ishiguro5, Yoshiya Tanaka6, Katsumi Eguchi7, Akira Watanabe8, Hideki Origasa9, Shinsuke Yasuda1, Yuji Yamanishi10, Yasuhiko Kita11, Tsukasa Matsubara12, Masahiro Iwamoto13, Toshiharu Shoji14, Toshiyuki Okada15, Désirée van der Heijde16, Nobuyuki Miyasaka17, Takao Koike18

Author Affiliations

1: Hokkaido University Graduate School of Medicine, Sapporo, Japan.
2: The University of Tokyo, Tokyo, Japan.
3: Keio University School of Medicine, Tokyo, Japan.
4: Tokyo Women's Medical University, Tokyo, Japan.
5: Faculty of Medicine, Nagoya University Graduate School, Nagoya, Japan.
6: University of Occupational and Environmental Health, Kitakyushu, Japan.
7: Sasebo Chuo Hospital, Nagasaki, Japan.
8: Tohoku University, Sendai, Japan.
9: University of Toyama School of Medicine, Toyama, Japan.
10: Hiroshima Rheumatology Clinic, Hiroshima, Japan.
11: Yokohama Rosai Hospital, Yokohama, Japan.
12: Matsubara Mayflower Hospital, Kato, Japan.
13: Jichi Medical University, Tochigi, Japan.
14: UCB Pharma, Tokyo, Japan.
15: Astellas Pharma Inc., Tokyo, Japan.
16: Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands.
17: Tokyo Medical and Dental University, Tokyo, Japan.
18: Hokkaido University Graduate School of Medicine, Sapporo, Japan NTT Sapporo Medical Centre, Sapporo, Japan.

Associated clinical trials:

Efficacy Confirmation Study of CDP870 in Early Rheumatoid Arthritis | NCT01451203

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