Published in Neoplasia on June 01, 2015
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc (2007) 12.39
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol (2006) 6.22
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity (2002) 6.10
Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J (1995) 3.59
Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol (2006) 2.69
Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice. J Exp Med (2003) 2.51
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res (2006) 2.24
T cell-independent interleukin 15Ralpha signals are required for bystander proliferation. J Exp Med (2001) 2.16
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol (2006) 2.03
Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem (1995) 1.90
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. Blood (2012) 1.90
Identification of a tumor-initiating stem cell population in human renal carcinomas. FASEB J (2008) 1.88
Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells. J Immunol (2004) 1.85
Interleukin 15 mediates epithelial changes in celiac disease. Gastroenterology (2000) 1.79
The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Bioessays (2006) 1.70
Nice neighborhood: emerging concepts of the stem cell niche. Cell (2014) 1.63
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med (2007) 1.42
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free Radic Biol Med (2009) 1.38
The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15. J Biol Chem (2000) 1.33
The innate NK cells, allograft rejection, and a key role for IL-15. J Immunol (2008) 1.29
Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors. Blood (2005) 1.22
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem (2001) 1.19
Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine. J Immunol (2007) 1.14
Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation. J Biol Chem (2007) 1.07
Differentiation therapy: targeting human renal cancer stem cells with interleukin 15. J Natl Cancer Inst (2011) 1.05
Airway epithelial IL-15 transforms monocytes into dendritic cells. Am J Respir Cell Mol Biol (2007) 1.03
IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis. J Clin Invest (2002) 1.03
Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling. J Immunol (2004) 1.02
The role of VHL in the regulation of E-cadherin: a new connection in an old pathway. Cell Cycle (2007) 0.92
Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res (2009) 0.91
Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition. Cancer Res (2009) 0.90
Status of PI3K/Akt/mTOR pathway inhibitors in lymphoma. Clin Lymphoma Myeloma Leuk (2014) 0.88
IL-15 protects intestinal epithelial cells. Eur J Immunol (2006) 0.88
Membrane-bound interleukin (IL)-15 on renal tumor cells rescues natural killer cells from IL-2 starvation-induced apoptosis. Cancer Res (2007) 0.87
Interleukin-15, a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells. J Am Soc Nephrol (1998) 0.86
Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway. PLoS One (2012) 0.85
Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15. Cytokine (1997) 0.84
Renal cells express a functional interleukin-15 receptor. Nephrol Dial Transplant (2005) 0.83
Interleukin-15 is a major regulator of the cell-microenvironment interactions in human renal homeostasis. Cytokine Growth Factor Rev (2012) 0.83
Association between renal injury and reduced interleukin-15 and interleukin-15 receptor levels in acute kidney injury. J Interferon Cytokine Res (2010) 0.82
IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem Biophys Res Commun (2002) 0.82
Autoinhibition of IL-15 expression in KC cells is ERK1/2 and PI3K dependent. Scand J Immunol (2008) 0.80
Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against SLE. Scand J Immunol (2009) 0.80
Sequential immune monitoring in patients with melanoma and renal cell carcinoma treated with high-dose interleukin-2: immune patterns and correlation with outcome. Cancer Immunol Immunother (2014) 0.77
Topical treatment of field cancerization. Cancer Treat Res (2009) 0.76