Published in PLoS One on July 15, 2015
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Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases. Mediators Inflamm (2017) 0.75
Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency. Oncotarget (2017) 0.75
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ADAMs in cancer cell proliferation and progression. Cancer Sci (2007) 2.69
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J (2003) 2.55
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Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest (2007) 2.29
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Current views on the function of the lymphatic vasculature in health and disease. Genes Dev (2010) 1.84
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med (2010) 1.80
Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair. Am J Pathol (2010) 1.77
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TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair. Am J Physiol Heart Circ Physiol (2008) 1.68
Role of ADAM17 in the ectodomain shedding of TNF-alpha and its receptors by neutrophils and macrophages. J Leukoc Biol (2007) 1.61
Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood (2008) 1.52
Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis. FASEB J (2007) 1.50
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? Clin Proteomics (2011) 1.50
Mechanisms of lymphatic metastasis. J Clin Invest (2014) 1.46
Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res (2010) 1.42
Transmural flow modulates cell and fluid transport functions of lymphatic endothelium. Circ Res (2010) 1.41
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat Commun (2011) 1.40
TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Res (2009) 1.34
Fibrosis is a key inhibitor of lymphatic regeneration. Plast Reconstr Surg (2009) 1.34
Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J Biol Chem (2008) 1.27
Cross-domain inhibition of TACE ectodomain. Proc Natl Acad Sci U S A (2011) 1.26
ADAM-17 expression in breast cancer correlates with variables of tumor progression. Clin Cancer Res (2007) 1.25
ADAM17 as a therapeutic target in multiple diseases. Curr Pharm Des (2009) 1.17
TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell (2009) 1.17
Lymphangiogenesis and cancer. Genes Cancer (2011) 1.16
Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy. Circulation (2006) 1.14
Telomerized human microvasculature is functional in vivo. Nat Biotechnol (2001) 1.14
Syndecan-4 phosphorylation is a control point for integrin recycling. Dev Cell (2013) 1.12
Involvement of HB-EGF and EGF receptor transactivation in TGF-beta-mediated fibronectin expression in mesangial cells. Kidney Int (2002) 1.10
Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells. Am J Pathol (2008) 1.09
ADAM17 promotes glioma cell malignant phenotype. Mol Carcinog (2011) 1.08
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res (2006) 1.04
TGFβ signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin. Development (2013) 1.03
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. J Biol Chem (2004) 1.03
Human papillomavirus type 16 E6 and E7 proteins inhibit differentiation-dependent expression of transforming growth factor-beta2 in cervical keratinocytes. Cancer Res (2000) 1.01
Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells. J Immunol (2014) 0.97
Up-regulated transforming growth factor beta-inducible gene h3 in rheumatoid arthritis mediates adhesion and migration of synoviocytes through alpha v beta3 integrin: Regulation by cytokines. Arthritis Rheum (2006) 0.97
ADAM-17: a novel therapeutic target for triple negative breast cancer. Ann Oncol (2012) 0.95
Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo. PLoS One (2013) 0.94
ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin. Oncogene (2010) 0.94
ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis. Biochem Biophys Res Commun (2009) 0.94
Lymphatic endothelial cells - key players in regulation of tolerance and immunity. Front Immunol (2012) 0.94
ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells. Mol Cancer (2012) 0.92
Telomerase-immortalized lymphatic and blood vessel endothelial cells are functionally stable and retain their lineage specificity. Microcirculation (2004) 0.90
Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide. EMBO Mol Med (2012) 0.89
TGFbeta-induced protein mediates lymphatic endothelial cell adhesion to the extracellular matrix under low oxygen conditions. Cell Mol Life Sci (2008) 0.89
Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk? J Signal Transduct (2011) 0.87
Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases. J Immunol (2013) 0.87
Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-β1 inhibition. Future Oncol (2011) 0.86
Integrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasis. Int J Cell Biol (2012) 0.84
Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17. Cell Death Dis (2014) 0.84
Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation. Lab Invest (2012) 0.83
TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells. Biochem Biophys Res Commun (2010) 0.83
ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. PLoS One (2012) 0.83
Cell invasion in the spheroid sprouting assay: a spatial organisation analysis adaptable to cell behaviour. PLoS One (2014) 0.81
Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells. Biol Cell (2007) 0.81
BIGH3 modulates adhesion and migration of hematopoietic stem and progenitor cells. Cell Adh Migr (2013) 0.77