Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study.

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Published in Blood on July 20, 2015

Authors

Jean Donadieu1, Frederic Bernard2, Max van Noesel3, Mohamed Barkaoui1, Odile Bardet4, Rosella Mura5, Maurizio Arico6, Christophe Piguet7, Virginie Gandemer8, Corinne Armari Alla9, Niels Clausen10, Eric Jeziorski2, Anne Lambilliote11, Sheila Weitzman12, Jan Inge Henter13, Cor Van Den Bos14, Salvage Group of the Histiocyte Society

Author Affiliations

1: Service d'Hémato-Oncologie Pédiatrique, Hopital Trousseau, Paris Registre des Histiocytoses Centre de Référence des Histiocytoses, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France;
2: Hémato Oncologie Pédiatrique, Centre Hospitalier Universitaire (CHU) de Montpellier, Montpellier, France;
3: Department of Pediatric Hematology Oncology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands;
4: Direction Recherche et Innovation, Centre Hospitalier Régional Universitaire (CHRU) Montpellier-Centre Administratif André Benech, Montpellier, France;
5: Pediatric Hematology Oncology, Ospedale microcetemico, Cagliari, Italy;
6: Pediatric Hematology Oncology, Azienda Sanitaria Provinciale, Ragusa, Italy;
7: Pediatric Hémato Oncology, CHU, Limoges, France;
8: Pediatric Hémato Oncology, CHU, Rennes, France;
9: Pediatric Hémato Oncology, CHU, Grenoble, France;
10: Pediatric Hematology Oncology, Universitets Hospital of Aarhus at Skejby, Aarhus, Denmark;
11: Pediatric Hémato Oncology, Hopital Jean De Flandre, CHU, Lille, France;
12: Pediatric Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada;
13: Department of Women's and Children's Health, Karolinska Institute, Karolinska Univeristy Hospital, Stockholm Sweden; and.
14: Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.

Associated clinical trials:

A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained Protocol | NCT04773366

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