Published in PLoS One on July 21, 2015
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82
Drug discovery: a historical perspective. Science (2000) 8.15
Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ. Proc Natl Acad Sci U S A (1988) 7.76
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature (1992) 7.66
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell (1993) 7.10
Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature (1994) 5.73
Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66
'Nude', a new hairless gene with pleiotropic effects in the mouse. Genet Res (1966) 4.89
Expression of the gamma-delta T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature (1988) 4.89
The gut-associated lymphoid system: nature and properties of the large dividing cells. Eur J Immunol (1974) 4.76
Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med (2002) 4.18
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04
Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity (2004) 3.75
Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med (1991) 3.63
Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function. J Exp Med (1989) 3.54
The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature (2008) 3.48
Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science (1994) 3.21
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature (1996) 3.11
Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (2002) 2.69
Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect Immun (1999) 2.50
Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. Proc Natl Acad Sci U S A (1991) 2.46
The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol (2011) 2.46
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev (2009) 2.46
Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science (1998) 2.32
A role for CCR9 in T lymphocyte development and migration. J Immunol (2002) 2.30
EBI2 mediates B cell segregation between the outer and centre follicle. Nature (2009) 2.20
Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity (2010) 2.11
Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol (1993) 2.05
Regional specialization within the intestinal immune system. Nat Rev Immunol (2014) 2.03
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood (2010) 2.02
The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat Immunol (2005) 1.98
The etiology of transmissible murine colonic hyperplasia. Lab Anim Sci (1976) 1.98
Gene Expression Commons: an open platform for absolute gene expression profiling. PLoS One (2012) 1.96
T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci U S A (1996) 1.92
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem (2009) 1.91
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity. Nat Immunol (2013) 1.86
Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells. Curr Protoc Immunol (2001) 1.83
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors. Blood (2010) 1.81
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A (2011) 1.80
Lineage specification and plasticity in CD19- early B cell precursors. J Exp Med (2006) 1.80
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun (2006) 1.79
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci (2010) 1.78
All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells. Cell Stem Cell (2011) 1.59
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nat Immunol (2012) 1.53
Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants. J Exp Med (2011) 1.53
Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injury. J Immunol (2009) 1.46
Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes. Eur J Immunol (1996) 1.45
Deficiency in IL-17-committed Vγ4(+) γδ T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat Immunol (2013) 1.43
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat Immunol (2006) 1.42
Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice. Gastroenterology (1997) 1.33
Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras. Radiat Res (1971) 1.32
Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine. Proc Natl Acad Sci U S A (2007) 1.31
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol (2012) 1.31
Adjuvant-specific regulation of long-term antibody responses by ZBTB20. J Exp Med (2014) 1.25
Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J Clin Invest (1998) 1.20
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood (2012) 1.19
CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells. Gastroenterology (2003) 1.19
Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage. Immunity (2014) 1.19
Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol (2007) 1.19
The mouse model for influenza. Curr Protoc Microbiol (2009) 1.16
Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol (1998) 1.15
Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria. Eur J Immunol (1993) 1.13
Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis. Genomics (1997) 1.12
FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells. Blood (2011) 1.03
Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity (1996) 0.98
Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation. J Immunol (2004) 0.98
Predominant donor CD103+CD8+ T cell infiltration into the gut epithelium during acute GvHD: a role of gut lymph nodes. Int Immunol (2008) 0.97
Resolution of inflammation by N-arachidonoylglycine. J Cell Biochem (2011) 0.96
Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. Br J Pharmacol (2014) 0.94
Pertussis toxin-sensitive G proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors. Blood (2009) 0.93
N-arachidonoyl glycine induces macrophage apoptosis via GPR18. Biochem Biophys Res Commun (2012) 0.91
Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsive. J Immunol (2004) 0.90
N-Arachidonyl glycine does not activate G protein-coupled receptor 18 signaling via canonical pathways. Mol Pharmacol (2012) 0.88
Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14. Mamm Genome (1996) 0.85
Host intestinal intraepithelial gamma delta T lymphocytes present during acute graft-versus-host disease in mice may contribute to the development of enteropathy. Eur J Immunol (1995) 0.85
Kinetics of intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice. Eur J Immunol (1994) 0.80
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. J Exp Med (2014) 0.80
ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Exp Hematol (2014) 0.80
Origins of intestinal intraepithelial lymphocytes: direct evidence for a thymus-derived gamma delta T cell component. Immunol Lett (2000) 0.77