Published in Semin Nephrol on May 01, 2015
APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes. J Am Soc Nephrol (2016) 1.11
Exploring the genetic basis of early-onset chronic kidney disease. Nat Rev Nephrol (2016) 0.94
Combined Effects of GSTM1 Null Allele and APOL1 Renal Risk Alleles in CKD Progression in the African American Study of Kidney Disease and Hypertension Trial. J Am Soc Nephrol (2016) 0.78
Beyond APOL1: Genetic Inroads into Understanding Population Disparities in Diabetic Kidney Disease. Clin J Am Soc Nephrol (2016) 0.76
Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection. J Acquir Immune Defic Syndr (2016) 0.75
APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease. Arterioscler Thromb Vasc Biol (2016) 0.75
Interferon Induced Focal Segmental Glomerulosclerosis. Case Rep Nephrol (2016) 0.75
Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure. JCI Insight (2016) 0.75
Chronic kidney disease in children. Clin Kidney J (2016) 0.75
The African diaspora: history, adaptation and health. Curr Opin Genet Dev (2016) 0.75
Apolipoprotein L1 risk variants associate with prevalent atherosclerotic disease in African American systemic lupus erythematosus patients. PLoS One (2017) 0.75
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science (2010) 16.00
Proteomics. Tissue-based map of the human proteome. Science (2015) 10.21
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science (2000) 8.74
The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ (2011) 5.95
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell (2008) 5.75
Lysosomes and autophagy in cell death control. Nat Rev Cancer (2005) 5.47
Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ (2005) 5.40
APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med (2013) 5.00
APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol (2011) 4.80
Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature (2003) 4.33
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science (2001) 4.29
The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant (2011) 3.69
Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int (2012) 3.46
JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int (2013) 3.09
Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science (2005) 3.06
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1. Kidney Int (2014) 2.83
Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol (2011) 2.81
Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arterioscler Thromb Vasc Biol (2009) 2.50
The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions. Genome Res (2009) 2.35
Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem (2008) 2.30
BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem (1997) 2.23
C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. PLoS Pathog (2009) 2.22
The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. Genomics (2002) 2.20
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. J Lipid Res (2001) 2.02
APOL1 variants associate with increased risk of CKD among African Americans. J Am Soc Nephrol (2013) 1.98
Cumulative risk for developing end-stage renal disease in the US population. J Am Soc Nephrol (2002) 1.93
Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. Mol Cancer Res (2005) 1.87
ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death. Autophagy (2008) 1.87
Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ Res (2013) 1.82
HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics. Kidney Int (2012) 1.79
The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. Genomics (2001) 1.77
The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival. Am J Transplant (2012) 1.73
APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans. J Am Soc Nephrol (2015) 1.73
Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Kidney Int (2014) 1.71
Genetic variation in APOL1 associates with younger age at hemodialysis initiation. J Am Soc Nephrol (2011) 1.70
MYH9 and APOL1 are both associated with sickle cell disease nephropathy. Br J Haematol (2011) 1.67
Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein. J Biol Chem (1989) 1.67
APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. J Am Soc Nephrol (2011) 1.67
Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy. J Am Soc Nephrol (2013) 1.66
Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection. PLoS Pathog (2009) 1.66
The trypanolytic factor of human serum. Nat Rev Microbiol (2006) 1.64
APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int (2014) 1.63
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol (2014) 1.62
Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A (2014) 1.61
Characterization of a novel trypanosome lytic factor from human serum. Infect Immun (1999) 1.49
The function of apolipoproteins L. Cell Mol Life Sci (2006) 1.48
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. J Exp Med (2008) 1.47
APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease. J Am Soc Nephrol (2011) 1.43
APOL1 allelic variants are associated with lower age of dialysis initiation and thereby increased dialysis vintage in African and Hispanic Americans with non-diabetic end-stage kidney disease. Nephrol Dial Transplant (2012) 1.42
Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol (2014) 1.42
High population frequencies of APOL1 risk variants are associated with increased prevalence of non-diabetic chronic kidney disease in the Igbo people from south-eastern Nigeria. Nephron Clin Pract (2013) 1.38
Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature. Mol Biol Cell (2013) 1.38
Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Am J Hum Genet (2013) 1.35
The kidney as a reservoir for HIV-1 after renal transplantation. J Am Soc Nephrol (2013) 1.34
Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. Int J Nephrol (2012) 1.31
Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes. Mol Biochem Parasitol (2005) 1.29
Mechanism of Trypanosoma brucei gambiense resistance to human serum. Nature (2013) 1.28
Glomerular podocytes contain neuron-like functional synaptic vesicles. FASEB J (2006) 1.27
APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability. Am J Physiol Renal Physiol (2014) 1.23
Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects. J Lipid Res (2000) 1.23
Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Proc Natl Acad Sci U S A (2002) 1.22
Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans. Nephrol Dial Transplant (2011) 1.18
APOL1 kidney risk alleles: population genetics and disease associations. Adv Chronic Kidney Dis (2014) 1.18
Plasma apolipoprotein L1 levels do not correlate with CKD. J Am Soc Nephrol (2013) 1.15
The innate immune factor apolipoprotein L1 restricts HIV-1 infection. J Virol (2013) 1.13
Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial. J Am Soc Nephrol (2015) 1.12
Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1. PLoS Negl Trop Dis (2011) 1.09
APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis. PLoS One (2012) 1.08
Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases. N Am J Med Sci (2012) 1.07
Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia. Transl Psychiatry (2013) 1.07
Mechanism of the process formation; podocytes vs. neurons. Microsc Res Tech (2002) 1.04
Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem (2011) 1.03
Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney Int (2013) 0.98
The trypanolytic factor-mechanism, impacts and applications. Trends Parasitol (2010) 0.97
Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease. FEBS Lett (2012) 0.95
The molecular arms race between African trypanosomes and humans. Nat Rev Microbiol (2014) 0.94
The new era of APOL1-associated glomerulosclerosis. Nephrol Dial Transplant (2012) 0.93
Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. PLoS One (2014) 0.92
Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene (2002) 0.91
Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL. J Lipid Res (2004) 0.91
Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. Proc Natl Acad Sci U S A (2015) 0.91
Mechanisms and biological functions of autophagy in diseased and ageing kidneys. Nat Rev Nephrol (2014) 0.90
A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology (2015) 0.89
BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. Am J Physiol Cell Physiol (2015) 0.88
The neurobiology of apolipoproteins in psychiatric disorders. Mol Neurobiol (2002) 0.85
APOL1 Risk Alleles Are Associated with Exaggerated Age-Related Changes in Glomerular Number and Volume in African-American Adults: An Autopsy Study. J Am Soc Nephrol (2015) 0.85
Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein. Cell Death Dis (2014) 0.84
Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. Schizophr Res (2005) 0.84
A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells. J Cell Physiol (2011) 0.84
Histopathologic effect of APOL1 risk alleles in PLA2R-associated membranous glomerulopathy. Am J Kidney Dis (2014) 0.83
Topological arrangement of the intracellular membrane fusion machinery. Mol Biol Cell (2011) 0.82
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. Kidney Int (2012) 0.82
Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. Schizophr Res (2008) 0.82
Testing the antagonistic pleiotropy model of schizophrenia susceptibility by analysis of DAOA, PPP1R1B, and APOL1 genes. Psychiatry Res (2010) 0.80
Collapsing glomerulopathy associated lupus in a black female with homozygous APOL1 mutation. Lupus (2012) 0.79