Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force.

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Published in J Prev Alzheimers Dis on June 01, 2015

Authors

B Vellas1, R Bateman2, K Blennow3, G Frisoni4, K Johnson5, R Katz6, J Langbaum7, D Marson8, R Sperling9, A Wessels10, S Salloway11, R Doody12, P Aisen13, Task Force Members

Author Affiliations

1: UMR1027 Inserm, F-31073, Toulouse, France ; University of Toulouse III, F-31073, France ; Gerontopole Toulouse, Toulouse University Hospital, F-31000, Toulouse, France.
2: Washington University School of Medicine, St. Louis, MO, USA.
3: University of Gothenburg, MöIndal Hospital, Sahlgrenska University Hospital, 43180 MöIndal, Sweden.
4: University Hospitals and University of Geneva, Geneva, Switzerland ; IRCCS Fatebenefratelli, Brescia, Italy.
5: Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.
6: Division of Neuropharmacological Drug Products, U.S. Food and Drug Administration, USA.
7: Banner Alzheimer's Institute, Phoenix, AZ, USA.
8: The University of Alabama at Birmingham, Birmingham, AL, USA.
9: Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
10: Eli Lilly and Company, Indianapolis, IN, USA.
11: The Warren Alpert Medical School of Brown University, Providence, RI, USA.
12: Baylor College of Medicine, Houston, TX, USA.
13: Department of Neurosciences, University of California, San Diego, San Diego, CA USA.

Associated clinical trials:

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU) | NCT01760005

A Study of Crenezumab Versus Placebo in Preclinical PSEN1 E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer Disease (AD), Including a Placebo-Treated Noncarrier Cohort | NCT01998841

Dose-Finding Study To Evaluate Safety, Tolerability, and Efficacy of E2609 in Subjects With Mild Cognitive Impairment Due to Alzheimer's Disease (Prodromal Alzheimer's Disease) and Mild to Moderate Dementia Due to Alzheimer's Disease | NCT02322021

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