Nanomedicine in the ROS-mediated pathophysiology: Applications and clinical advances.

Effects of copper oxide nanoparticles on developing zebrafish embryos and larvae. Int J Nanomedicine (2016) 0.75

Autophagy and mitochondrial dysfunction in adjuvant-arthritis rats treatment with resveratrol. Sci Rep (2016) 0.75

Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1α expression and mitochondrial ROS production. PLoS One (2017) 0.75

Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol (2006) 21.58

Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect (2005) 17.71

NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87

Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol (2008) 5.03

Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72

The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res (2006) 3.83

The chemistry and biology of nitroxide compounds. Free Radic Biol Med (2007) 2.76

Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther (1994) 2.61

Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol (2007) 2.50

Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem Commun (Camb) (2007) 2.42

Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis (2003) 2.31

Oxidative stress and neurotoxicity. Chem Res Toxicol (2007) 2.12

Structure and function of xanthine oxidoreductase: where are we now? Free Radic Biol Med (2002) 2.06

The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials (2008) 2.04

Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res (2008) 1.96

Anaerobic gene expression in Staphylococcus aureus. J Bacteriol (2007) 1.95

Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A (2004) 1.91

Anti-inflammatory properties of cerium oxide nanoparticles. Small (2009) 1.86

The big picture on nanomedicine: the state of investigational and approved nanomedicine products. Nanomedicine (2012) 1.83

Nanoceria exhibit redox state-dependent catalase mimetic activity. Chem Commun (Camb) (2010) 1.65

Ageing, oxidative stress and cancer: paradigms in parallax. Nat Rev Cancer (2008) 1.60

The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res (1992) 1.48

Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke (2005) 1.47

Spin traps: in vitro toxicity and stability of radical adducts. Free Radic Biol Med (2003) 1.38

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes (2015) 1.33

Application of a trityl-based radical probe for measuring superoxide. Free Radic Biol Med (2003) 1.29

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc Natl Acad Sci U S A (2012) 1.27

Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury. FASEB J (2009) 1.26

Physiologically based pharmacokinetic modeling of nanoparticles. ACS Nano (2010) 1.26

Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. Subcell Biochem (2007) 1.23

Silver nanoparticles as potential antibacterial agents. Molecules (2015) 1.18

The reaction of superoxide radical with N-acetylcysteine. Free Radic Biol Med (2000) 1.16

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines. Free Radic Res (2010) 1.15

Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci U S A (2002) 1.15

The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther (2008) 1.15

Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide. Free Radic Res (2007) 1.14

Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res (1997) 1.10

Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. ACS Nano (2012) 1.08

Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise. Arthritis Res Ther (2010) 1.07

Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke (2013) 1.07

Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase. J Biol Chem (2006) 1.04

Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical. J Phys Chem B (2007) 1.02

Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model. Neuroscience (2009) 1.01

Reactive oxygen species in the cerebral circulation: are they all bad? Antioxid Redox Signal (2006) 0.99

In vitro free radical scavenging activity of platinum nanoparticles. Nanotechnology (2009) 0.96

Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans (2011) 0.96

An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice. Gastroenterology (2012) 0.95

Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice. J Pharmacol Exp Ther (2009) 0.94

Improved spin trapping properties by beta-cyclodextrin-cyclic nitrone conjugate. J Org Chem (2008) 0.94

Intracellular pH and Ca2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes. Am J Physiol (1993) 0.94

Phenyl N-tert-butylnitrone down-regulates interleukin-1 beta-stimulated matrix metalloproteinase-13 gene expression in human chondrocytes: suppression of c-Jun NH2-terminal kinase, p38-mitogen-activated protein kinase and activating protein-1. J Pharmacol Exp Ther (2003) 0.93

The Role of p21 in Apoptosis, Proliferation, Cell Cycle Arrest, and Antioxidant Activity in UVB-Irradiated Human HaCaT Keratinocytes. Med Sci Monit Basic Res (2015) 0.91

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-acetylcysteine. Brain Behav Immun (2012) 0.89

Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059. Free Radic Res (2001) 0.89

Oxidative stress in Alzheimer's disease: are we connecting the dots? J Med Chem (2013) 0.89

Dietary antioxidants in inflammatory arthritis: do they have any role in etiology or therapy? Nat Clin Pract Rheumatol (2008) 0.89

A new strategy for intracellular delivery of enzyme using mesoporous silica nanoparticles: superoxide dismutase. J Am Chem Soc (2013) 0.88

Newly synthesized radical-containing nanoparticles enhance neuroprotection after cerebral ischemia-reperfusion injury. Neurosurgery (2011) 0.88

Stable nitroxide Tempol ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischemia. Brain Res (2003) 0.88

H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents. Sci Rep (2013) 0.88

Cerium oxide nanoparticles: a promise for applications in therapy. J Exp Ther Oncol (2011) 0.88

Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future Med Chem (2012) 0.86

Fast reactivity of a cyclic nitrone-calix[4]pyrrole conjugate with superoxide radical anion: theoretical and experimental studies. J Am Chem Soc (2010) 0.85

Cerium oxide nanoparticles accelerate the decay of peroxynitrite (ONOO(-)). Drug Deliv Transl Res (2013) 0.84

Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke (2000) 0.84

The effect of TAT conjugated platinum nanoparticles on lifespan in a nematode Caenorhabditis elegans model. Biomaterials (2010) 0.83

Infarct Size Limitation: acute N-acetylcysteine defense (ISLAND trial): preliminary analysis and report after the first 30 patients. Clin Cardiol (1996) 0.83

Antiproliferative effect of the piperidine nitroxide TEMPOL on neoplastic and nonneoplastic mammalian cell lines. Free Radic Biol Med (1998) 0.82

NXY-059, a nitrone with free radical trapping properties inhibits release of cytochrome c after focal cerebral ischemia. Cell Mol Biol (Noisy-le-grand) (2003) 0.80

Recovery of Cognitive Dysfunction via Orally Administered Redox-Polymer Nanotherapeutics in SAMP8 Mice. PLoS One (2015) 0.80

Reactive nitrogen species reactivities with nitrones: theoretical and experimental studies. Chem Res Toxicol (2012) 0.78

NXY-059 for the treatment of stroke. N Engl J Med (2007) 0.76

UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion. Neurosci Lett (2014) 0.76

Nitrones are able to release nitric oxide in aqueous environment under hydroxyl free radical attack. Nitric Oxide (2011) 0.76

Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation. Toxicol Appl Pharmacol (2015) 0.76

Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts. Toxicol Appl Pharmacol (2017) 0.75