Published in Chem Biol on August 06, 2015
Irreversible inhibitors of serine, cysteine, and threonine proteases. Chem Rev (2002) 4.57
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci U S A (1997) 2.81
Activity-based probes that target diverse cysteine protease families. Nat Chem Biol (2005) 2.21
Two new proteases in the MHC class I processing pathway. Nat Immunol (2000) 1.63
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chem Biol (2006) 1.54
Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Science (1995) 1.34
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem (2009) 1.33
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes. Chem Biol (2010) 1.20
Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids. J Biol Chem (2009) 1.19
Activity-based profiling of proteases. Annu Rev Biochem (2014) 1.10
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C. J Am Chem Soc (2006) 1.09
Studies on the mechanism of antitumor effect of bleomycin of squamous cell carcinoma. J Antibiot (Tokyo) (1972) 1.01
Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. J Biol Chem (2006) 1.00
The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Proc Natl Acad Sci U S A (1999) 0.99
Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. FASEB J (2000) 0.99
Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. Nat Genet (1998) 0.96
Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. Biochemistry (1996) 0.94
Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses. J Immunol (2007) 0.90
One-carbon chain extension of esters to alpha-chloroketones: a safer route without diazomethane. J Org Chem (2004) 0.88
Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner. J Immunol (2009) 0.88
The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell (1998) 0.88
Reduced homocysteine-thiolactonase activity in Alzheimer's disease. J Alzheimers Dis (2010) 0.86
Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure (1999) 0.84
Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis. J Biol Chem (2010) 0.82
Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One (2014) 0.82
Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids. Biol Chem (2015) 0.80
Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase. Amino Acids (2012) 0.80
Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing. Biochem Biophys Res Commun (2001) 0.80
Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease. Mol Psychiatry (2000) 0.79
Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase. Neuroscience (2007) 0.79