Neratinib shows efficacy in the treatment of HER2 amplified carcinosarcoma in vitro and in vivo.

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🔗 View Article (PMID 26260909)

Published in Gynecol Oncol on August 08, 2015

Authors

Carlton L Schwab1, Diana P English1, Jonathan Black1, Stefania Bellone1, Salvatore Lopez2, Emiliano Cocco1, Elena Bonazzoli1, Beatrice Bussi1, Federica Predolini1, Francesca Ferrari1, Elena Ratner1, Dan-Arin Silasi1, Masoud Azodi1, Thomas Rutherford1, Peter E Schwartz1, Alessandro D Santin3

Author Affiliations

1: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street New Haven, CT 06520, United States.
2: Division of Gynecologic Oncology, University Campus Biomedico of Roma, Via Álvaro del Portillo, 21-00128 Rome, Italy.
3: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street New Haven, CT 06520, United States. Electronic address: Alessandro.santin@yale.edu.

Associated clinical trials:

I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY 2) | NCT01042379

Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer | NCT01111825

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases | NCT01494662

Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Cancer | NCT01827267

Phase II Randomized Trial Evaluating Neoadjuvant Therapy With Neratinib and/or Trastuzumab Followed by Postoperative Trastuzumab in Women With Locally Advanced HER2-positive Breast Cancer | NCT01008150

Neratinib +/- Fulvestrant in Metastatic HER2 Non-amplified But HER2 Mutant Breast Cancer | NCT01670877

A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic Setting (NALA) | NCT01808573

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