Treatment of systemic lupus erythematosus patients with the BAFF antagonist "peptibody" blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials.

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Published in Arthritis Res Ther on August 20, 2015

Authors

William Stohl1,2, Joan T Merrill3, R John Looney4, Jill Buyon5, Daniel J Wallace6, Michael H Weisman7, Ellen M Ginzler8, Blaire Cooke9, Donna Holloway10, Arunan Kaliyaperumal11, Kameswara Rao Kuchimanchi12, Tsui Chern Cheah13, Erik Rasmussen14, John Ferbas15, Shelley S Belouski16, Wayne Tsuji17, Debra J Zack18

Author Affiliations

1: Los Angeles County and University of Southern California Medical Center and University of Southern California Keck School of Medicine, 1975 Zonal Ave., Los Angeles, CA, 90033, USA. stohl@usc.edu.
2: Division of Rheumatology, Los Angeles County + University of Southern California Medical Center and Keck School of Medicine of the University of Southern California, 2011 Zonal Ave., Los Angeles, CA, 90033, USA. stohl@usc.edu.
3: Oklahoma Medical Research Foundation, 825 NE 13th St., Oklahoma City, OK, 73104, USA. JTMmail@aol.com.
4: University of Rochester, 252 Elmwood Ave., Rochester, NY, 14627, USA. John_Looney@URMC.Rochester.edu.
5: Hospital for Joint Disease, 301 E 17th St., New York, NY, 10003, USA. Jbuyonic@aol.com.
6: Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA. drdanielwallace@gmail.com.
7: Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA. Michael.Weisman@cshs.org.
8: SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA. ELLEN.GINZLER@downstate.edu.
9: Amgen Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. bcooke@amgen.com.
10: Formerly of Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. donnalholloway@yahoo.com.
11: Amgen Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. arunank@amgen.com.
12: Formerly of Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. Kamesh.Kuchimanchi@baxalta.com.
13: Amgen Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. tcheah@amgen.com.
14: Amgen Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. hansr@amgen.com.
15: Amgen Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. jferbas@amgen.com.
16: Formerly of Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. sbelouski@yahoo.com.
17: Amgen Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. tsujiw@amgen.com.
18: Formerly of Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. djzk3tk@msn.com.

Associated clinical trials:

A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of Single Dose of AMG 623 in Subjects With Systemic Lupus Erythematosus | NCT02443506

A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of AMG 623 in Subjects With Systemic Lupus Erythematosus | NCT02411136

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