Published in Sci Rep on September 02, 2015
Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer (2009) 11.25
Cdk1 is sufficient to drive the mammalian cell cycle. Nature (2007) 4.26
New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev (2008) 2.74
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood (2008) 2.22
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc (2005) 2.11
An overview of Cdk1-controlled targets and processes. Cell Div (2010) 1.66
Baicalein selectively induces apoptosis in activated lymphocytes and ameliorates concanavalin a-induced hepatitis in mice. PLoS One (2013) 1.48
Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Cancer Res (2008) 1.25
Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology (2000) 1.22
Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res (2003) 1.20
Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Med (2002) 1.20
In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00. Mol Cancer Ther (2007) 1.18
Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta (2011) 1.17
Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. Mol Cancer Ther (2007) 1.17
Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun (2000) 1.16
The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells. Nutr Cancer (2009) 1.13
The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res (2008) 1.10
In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. Planta Med (2008) 1.09
Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res (2005) 1.06
ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. Anticancer Res (2007) 1.05
Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Biol Pharm Bull (2003) 1.03
Baicalein, a novel apoptotic agent for hepatoma cell lines: a potential medicine for hepatoma. Nutr Cancer (2000) 1.02
Differential modulation of normal and tumor cell proliferation by reactive oxygen species. Biomed Pharmacother (2005) 1.01
Role of intestinal first-pass metabolism of baicalein in its absorption process. Pharm Res (2005) 1.01
Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food Chem Toxicol (2006) 1.01
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma. Leukemia (2009) 0.99
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther (2007) 0.98
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim Biophys Acta (2007) 0.98
A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors. Invest New Drugs (2010) 0.96
What's new on CDC25 phosphatase inhibitors. Pharmacol Ther (2007) 0.94
CDK inhibitors: from the bench to clinical trials. Curr Drug Targets (2010) 0.94
Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest New Drugs (2009) 0.93
Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. J Chromatogr A (2005) 0.92
Comparison of the metabolism of baicalin in rats orally administered with Radix scutellariae extract and Shuang-Huang-Lian extract. Chem Pharm Bull (Tokyo) (2005) 0.92
Baicalin induces apoptosis via mitochondrial pathway as prooxidant. Mol Immunol (2002) 0.92
Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells. Int J Oncol (2009) 0.92
Investigation of flavonoid profile of Scutellaria bacalensis Georgi by high performance liquid chromatography with diode array detection and electrospray ion trap mass spectrometry. J Chromatogr A (2009) 0.91
Whether to target single or multiple CDKs for therapy? That is the question. J Cell Physiol (2011) 0.90
Baicalein-induced apoptosis via endoplasmic reticulum stress through elevations of reactive oxygen species and mitochondria dependent pathway in mouse-rat hybrid retina ganglion cells (N18). Neurochem Res (2008) 0.86
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur J Pharmacol (2001) 0.85
Baicalein induces apoptosis in SCC-4 human tongue cancer cells via a Ca2+-dependent mitochondrial pathway. In Vivo (2008) 0.85
Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity. Bioorg Med Chem (2008) 0.82
Pharmacokinetic study of baicalein after oral administration in monkeys. Fitoterapia (2012) 0.82
Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. Evid Based Complement Alternat Med (2013) 0.82
Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. J Pharm Pharmacol (2007) 0.81
Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. Biosci Biotechnol Biochem (2004) 0.80
[The chemical structure of new substance as the metabolite of baicalin and time profiles for the plasma concentration after oral administration of sho-saiko-to in human]. Yakugaku Zasshi (1998) 0.78
Cyclane-aminol 10-hydroxycamptothecin analogs as novel DNA topoisomerase I inhibitors induce apoptosis selectively in tumor cells. Anticancer Drugs (2014) 0.76