Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females.

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Published in Aging (Albany NY) on August 01, 2015

Authors

Davide Gentilini1, Paolo Garagnani2,3, Serena Pisoni1, Maria Giulia Bacalini2,3, Luciano Calzari1, Daniela Mari4, Giovanni Vitale1,5, Claudio Franceschi2,3, Anna Maria Di Blasio1

Author Affiliations

1: Istituto Auxologico Italiano IRCCS, Cusano Milanino, 20095 Milan, Italy.
2: Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum- University of Bologna, Bologna 40138, Italy.
3: Interdepartmental Center "L. Galvani", University of Bologna, Bologna 40126, Italy.
4: Geriatric Unit, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
5: Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

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