Update on the Development of Anti-Viral Agents Against Hepatitis C.

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Published in J Clin Transl Hepatol on September 15, 2013

Authors

Kristin L Macarthur1, Robert Smolic2, Martina V Smolic2, Catherine H Wu3, George Y Wu3

Author Affiliations

1: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA02215.
2: Faculty of Medicine, Osijek, Croatia.
3: Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA.

Associated clinical trials:

A Safety and Effectiveness Study of TMC435 in Chronic, Genotype 1, Hepatitis C Patients Who Failed to Previous Standard Treatment (ASPIRE) | NCT00980330

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Complete replication of hepatitis C virus in cell culture. Science (2005) 18.59

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84

Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2005) 14.78

Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44

Binding of hepatitis C virus to CD81. Science (1998) 12.40

Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med (2009) 12.07

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30

Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med (2009) 10.21

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature (2007) 9.52

Internal ribosome entry site within hepatitis C virus RNA. J Virol (1992) 9.14

Telaprevir for previously treated chronic HCV infection. N Engl J Med (2010) 8.33

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol (1993) 8.07

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature (2009) 8.05

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J (2002) 7.93

A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev (1998) 7.72

Epidemiology of hepatitis C virus infection. World J Gastroenterol (2007) 7.36

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol (2002) 6.69

Course and outcome of hepatitis C. Hepatology (2002) 6.51

Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med (2012) 6.44

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med (2011) 6.21

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med (2007) 6.05

Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J Gen Virol (1993) 5.26

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci U S A (1996) 4.82

SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders. Gastroenterology (2007) 4.44

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol (1999) 4.37

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A (1999) 3.77

Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med (2000) 3.74

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci U S A (1994) 3.56

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders. Hepatology (2012) 3.54

Exploratory study of oral combination antiviral therapy for hepatitis C. N Engl J Med (2013) 3.52

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol (1995) 3.41

The burden of hepatitis C in the United States. Hepatology (2002) 3.16

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04

Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines. J Virol (2000) 2.89

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Unscrambling hepatitis C virus-host interactions. Nature (2005) 2.83

Identification of hepatitis C virus NS5A inhibitors. J Virol (2010) 2.58

Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J Virol (1995) 2.57

In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor. J Virol (2003) 2.55

Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother (2010) 2.50

The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation. Proc Natl Acad Sci U S A (1997) 2.43

American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology (2006) 2.39

Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner. J Virol (2004) 2.26

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An enzymatic footprinting analysis of the interaction of 40S ribosomal subunits with the internal ribosomal entry site of hepatitis C virus. J Virol (2000) 2.21

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Monoclonal antibody HCV-AbXTL68 in patients undergoing liver transplantation for HCV: results of a phase 2 randomized study. Liver Transpl (2006) 2.12

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Structure and function of HCV IRES domains. Virus Res (2008) 1.81

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Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites. C R Biol (2005) 1.65

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hnRNP C and polypyrimidine tract-binding protein specifically interact with the pyrimidine-rich region within the 3'NTR of the HCV RNA genome. Nucleic Acids Res (1999) 1.34

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Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. Antimicrob Agents Chemother (2008) 1.18

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Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3. Proc Natl Acad Sci U S A (2009) 1.14

RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients. J Infect Dis (2010) 1.14

A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipients. Liver Transpl (2005) 1.13

Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor. Arterioscler Thromb Vasc Biol (2009) 1.11

Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection. Proc Natl Acad Sci U S A (2009) 1.11

The domains of polypyrimidine tract binding protein have distinct RNA structural preferences. Biochemistry (2009) 1.10

Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells. J Virol (2008) 1.09

The emerging field of HCV drug resistance. Expert Opin Investig Drugs (2008) 1.05

Lower concentration of La protein required for internal ribosome entry on hepatitis C virus RNA than on poliovirus RNA. J Gen Virol (1999) 1.03

Treatment failure in hepatitis C: mechanisms of non-response. J Hepatol (2008) 1.02

Predictors of sustained response to alpha interferon therapy in chronic hepatitis C. J Hepatol (1998) 1.00

The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. J Virol (2010) 1.00

The FUSE binding protein is a cellular factor required for efficient replication of hepatitis C virus. J Virol (2008) 0.98

A new era of hepatitis C therapy begins. N Engl J Med (2011) 0.97