Published in Am J Physiol Regul Integr Comp Physiol on September 16, 2015
Cardiac responses to hypoxia and reoxygenation in Drosophila. New insights into evolutionarily conserved gene responses. Focus on "Cardiac responses to hypoxia and reoxygenation in Drosophila". Am J Physiol Regul Integr Comp Physiol (2015) 0.75
Effect of localized hypoxia on Drosophila embryo development. PLoS One (2017) 0.75
Oxygen sensing, homeostasis, and disease. N Engl J Med (2011) 5.03
Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation (2006) 4.69
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest (1999) 4.00
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci U S A (2007) 3.30
The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study. Circulation (2014) 2.99
Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol (1999) 2.55
Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev (2011) 2.37
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques (2009) 2.30
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness. Circulation (2007) 2.19
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest (2003) 2.00
Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta (2010) 2.00
Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol (2005) 1.85
Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Mol Cell Biol (2002) 1.83
Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A (2011) 1.60
Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates. J Exp Biol (2010) 1.55
Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J (2004) 1.53
Hypoxia and myocardial remodeling in human cardiac allografts: a time-course study. J Heart Lung Transplant (2009) 1.52
Hypoxia-inducible factor 1 and cardiovascular disease. Annu Rev Physiol (2013) 1.52
The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc Natl Acad Sci U S A (2006) 1.51
Genetic control of heart function and aging in Drosophila. Trends Cardiovasc Med (2007) 1.43
Physiological adaptation to high altitude: oxygen transport in mammals and birds. Physiol Rev (1991) 1.41
Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet (2008) 1.36
A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet (2014) 1.35
Hypoxia tolerance in mammals and birds: from the wilderness to the clinic. Annu Rev Physiol (2007) 1.30
Behavioral and Electrophysiologic Responses of Drosophila melanogaster to Prolonged Periods of Anoxia. J Insect Physiol (1997) 1.28
Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis. Mol Syst Biol (2007) 1.28
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Med (Berl) (2007) 1.25
Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int Rev Cell Mol Biol (2012) 1.21
Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima. EMBO Rep (2005) 1.19
Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns. PLoS One (2008) 1.15
Common threads in cardiac fibrosis, infarct scar formation, and wound healing. Fibrogenesis Tissue Repair (2012) 1.12
Visualizing the beating heart in Drosophila. J Vis Exp (2009) 1.12
Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts. J Comp Physiol B (2007) 1.09
Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha. Biochem Biophys Res Commun (1998) 1.07
Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet (2013) 1.06
Heart failure after myocardial infarction: clinical implications and treatment. Clin Cardiol (2011) 1.03
Assessing the Global Burden of Ischemic Heart Disease: Part 1: Methods for a Systematic Review of the Global Epidemiology of Ischemic Heart Disease in 1990 and 2010. Glob Heart (2012) 0.99
Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations. PLoS One (2014) 0.96
The Andean adaptive toolkit to counteract high altitude maladaptation: genome-wide and phenotypic analysis of the Collas. PLoS One (2014) 0.94
Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol (2009) 0.92
Developmental functional adaptation to high altitude: review. Am J Hum Biol (2013) 0.90
Evolution of air breathing: oxygen homeostasis and the transitions from water to land and sky. Compr Physiol (2013) 0.90
Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. G3 (Bethesda) (2012) 0.88
Drosophila melanogaster as a model system for genetics of postnatal cardiac function. Drug Discov Today Dis Models (2008) 0.87
King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude. Physiology (Bethesda) (2014) 0.85
Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet (2013) 0.84
The genetic basis of chronic mountain sickness. Physiology (Bethesda) (2014) 0.82
The heart as a working model to explore themes and strategies for anoxic survival in ectothermic vertebrates. Comp Biochem Physiol A Mol Integr Physiol (2007) 0.82
Survival in acute and severe low o environment: use of a genetic model system. Ann N Y Acad Sci (2009) 0.81
Study on Tibetan Chicken embryonic adaptability to chronic hypoxia by revealing differential gene expression in heart tissue. Sci China C Life Sci (2009) 0.81
Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Ann N Y Acad Sci (2008) 0.80