Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.

Fluorescent-Guided Surgical Resection of Glioma with Targeted Molecular Imaging Agents: A Literature Review. World Neurosurg (2016) 0.78

Surface biotinylation of cytotoxic T lymphocytes for in vivo tracking of tumor immunotherapy in murine models. Cancer Immunol Immunother (2016) 0.75

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57

Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol (2006) 11.56

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol (1999) 8.46

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nat Med (2011) 7.82

Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med (1991) 6.39

Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol (2002) 6.06

Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol (2011) 5.75

Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet (2002) 5.64

Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol (1996) 5.40

Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06

Molecular imaging in cancer. Science (2006) 5.01

In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat Med (2001) 4.30

Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study. Radiology (2008) 4.15

A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96

Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol (1996) 3.85

Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20. J Clin Oncol (2010) 3.79

Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev (2013) 3.44

Prospects for in vivo Raman spectroscopy. Phys Med Biol (2000) 3.32

Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol (2012) 3.18

Photoacoustic imaging and characterization of the microvasculature. J Biomed Opt (2010) 3.07

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A (2010) 3.03

Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update. Open Surg Oncol J (2010) 2.50

Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chem Rev (2010) 2.27

Unraveling the role of proteases in cancer. Clin Chim Acta (2000) 2.27

Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. Neurosurgery (1998) 2.22

In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy. Cancer Res (2006) 2.12

Intraoperative brain cancer detection with Raman spectroscopy in humans. Sci Transl Med (2015) 1.89

Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX--a pilot study. Gut (1995) 1.89

cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem Int Ed Engl (2004) 1.63

Intraoperative near-infrared fluorescence tumor imaging with vascular endothelial growth factor and human epidermal growth factor receptor 2 targeting antibodies. J Nucl Med (2011) 1.62

Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins. J Am Coll Surg (2005) 1.57

A prospective, randomized, controlled, multicenter study of a real-time, intraoperative probe for positive margin detection in breast-conserving surgery. Am J Surg (2008) 1.48

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. Curr Opin Chem Biol (2011) 1.31

Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging. Sci Transl Med (2015) 1.27

A systems approach for tumor pharmacokinetics. PLoS One (2011) 1.27

Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes. Invest Radiol (2005) 1.22

A device for real-time, intraoperative margin assessment in breast-conservation surgery. Am J Surg (2007) 1.22

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc (2013) 1.14

Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green. Int J Cancer (2011) 1.12

Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer (2012) 1.11

Current concepts and future perspectives on surgical optical imaging in cancer. J Biomed Opt (2011) 1.08

Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med (2015) 1.07

Real-time intraoperative detection of breast cancer using near-infrared fluorescence imaging and Methylene Blue. Eur J Surg Oncol (2014) 1.06

Fluorescently labeled therapeutic antibodies for detection of microscopic melanoma. Laryngoscope (2013) 1.04

Predicting the risk of local recurrence in patients with breast cancer: an approach to a new computer-based predictive tool. Am J Clin Oncol (2007) 1.04

Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial. Ann Surg Oncol (2014) 1.03

Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma. PLoS One (2013) 1.01

Optical imaging of cancer-related proteases using near-infrared fluorescence matrix metalloproteinase-sensitive and cathepsin B-sensitive probes. Theranostics (2012) 1.00

Tumor detection and visualization using cyanine fluorochrome-labeled antibodies. Biotechnol Prog (1997) 0.93

Active targeting using HER-2-affibody-conjugated nanoparticles enabled sensitive and specific imaging of orthotopic HER-2 positive ovarian tumors. Small (2013) 0.93

A multimodal contrast agent for preoperative MR Imaging and intraoperative tumor margin delineation. Technol Cancer Res Treat (2006) 0.91

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins. Chem Biol (2015) 0.91

In vivo cancer targeting and imaging-guided surgery with near infrared-emitting quantum dot bioconjugates. Theranostics (2012) 0.90

Photodynamic therapy for non-melanoma skin cancer. J Natl Compr Canc Netw (2007) 0.90

In vivo intraoperative confocal microscopy for real-time histopathological imaging of brain tumors. J Neurosurg (2012) 0.90

Pathologic prognostic factors in the recurrence of rectal cancer. Clin Colorectal Cancer (2002) 0.86

A handheld fluorescence molecular tomography system for intraoperative optical imaging of tumor margins. Med Phys (2011) 0.86

Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents. Int J Radiat Oncol Biol Phys (2013) 0.84

Toward nodal staging of axillary lymph node basins through intradermal administration of fluorescent imaging agents. Biomed Opt Express (2013) 0.82

Potential application of a handheld confocal endomicroscope imaging system using a variety of fluorophores in experimental gliomas and normal brain. Neurosurg Focus (2014) 0.81

In vivo optical imaging of folate receptor-β in head and neck squamous cell carcinoma. Laryngoscope (2014) 0.79

Breast Cancer Stem Cell Correlates as Predicative Factors for Radiation Therapy. Semin Radiat Oncol (2015) 0.78

In vivo assessment of HER2 receptor density in HER2-positive tumors by near-infrared imaging, using repeated injections of the fluorescent probe. Technol Cancer Res Treat (2013) 0.78

Optical imaging of ovarian cancer using HER-2 affibody conjugated nanoparticles. Methods Mol Biol (2015) 0.76