Triple negative breast cancer: looking for the missing link between biology and treatments.

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🔗 View Article (PMID 26387133)

Published in Oncotarget on September 29, 2015

Authors

Giuseppe Palma1, Giuseppe Frasci2, Andrea Chirico3,4, Emanuela Esposito2, Claudio Siani2, Carmela Saturnino5, Claudio Arra1, Gennaro Ciliberto6, Antonio Giordano3,7, Massimiliano D'Aiuto2

Author Affiliations

1: S.S.D. "Sperimentazione Animale", National Cancer Institute, IRCCS, "Fondazione Pascale", Naples, Italy.
2: Division of Breast Surgery, Department of Breast Disease, National Cancer Institute, IRCCS, "Fondazione Pascale", Naples, Italy.
3: Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA, USA.
4: Department of Psychology of Developmental and Socialisation Processes, "La Sapienza" University of Rome, Rome, Italy.
5: Department of Pharmacy and Biomedical Science, University of Salerno, Fisciano SA, Italy.
6: National Cancer Institute, IRCCS, "Fondazione Pascale", Naples, Italy.
7: Department of Medicine, Surgery and Neuroscience, "University of Siena", Siena, Italy.

Associated clinical trials:

I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY 2) | NCT01042379

Phase I Study of the Oral PI3kinase Inhibitor BKM120 or BYL719 and the Oral PARP Inhibitor Olaparib in Patients With Recurrent Triple Negative Breast Cancer or High Grade Serous Ovarian Cancer | NCT01623349

Safety and Efficacy Study of Enzalutamide in Patients With Advanced, Androgen Receptor-Positive, Triple Negative Breast Cancer | NCT01889238

A Trial of BKM120 (a PI3K Inhibitor) in Patients With Triple Negative Metastatic Breast Cancer | NCT01629615

A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer | NCT02032277

Cetuximab and Cisplatin in the Treatment of "Triple Negative" (Estrogen Receptor [ER] Negative, Progesterone Receptor [PgR] Negative, and Human Epidermal Growth Factor Receptor 2 [HER2] Negative) Metastatic Breast Cancer (BALI-1) | NCT00463788

GDC-0941 and Cisplatin in Treating Patients With Androgen Receptor-Negative Triple Negative Metastatic Breast Cancer | NCT01918306

A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto) | NCT02125344

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