Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls.

PubWeight™: 0.84‹?›

🔗 View Article (PMC 4595747)

Published in Nat Commun on September 22, 2015

Authors

Zezhang Zhu1,2, Nelson Leung-Sang Tang2,3,4,5, Leilei Xu1,2, Xiaodong Qin1,2, Saihu Mao1, Yueming Song6, Limin Liu6, Fangcai Li7, Peng Liu8, Long Yi9, Jiang Chang10, Long Jiang11, Bobby Kin-Wah Ng12, Benlong Shi1, Wen Zhang1, Jun Qiao1,2, Xu Sun1,2, Xusheng Qiu1,2, Zhou Wang1, Fei Wang1, Dingding Xie1, Ling Chen1, Zhonghui Chen1, Mengran Jin1, Xiao Han1, Zongshan Hu1, Zhen Zhang1, Zhen Liu1, Feng Zhu1, Bang-Ping Qian1,2, Yang Yu1,2, Bing Wang1,2, K M Lee5, Wayne Y W Lee12, T P Lam12, Yong Qiu1,2, Jack Chun-Yiu Cheng2,5,12

Author Affiliations

1: Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
2: Joint Scoliosis Research Center of The Chinese University of Hong Kong and Nanjing University, Nanjing 210008, China.
3: Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
4: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
5: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
6: Department of Orthopaedic, The West China Hospital, Sichuan University, Chengdu 610000, China.
7: Department of Orthopaedic, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.
8: Department of Orthopaedic, China-Japan Union Hospital of Jilin University, Changchun 130022, China.
9: Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing 210008, China.
10: State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment &Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
11: Department of Orthopaedic, Yixing People Hospital, Wuxi 214200, China.
12: Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Articles cited by this

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst (1959) 94.48

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res (2011) 11.03

The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions. Annu Rev Cell Dev Biol (2007) 2.81

A genetic survey of idiopathic scoliosis in Boston, Massachusetts. J Bone Joint Surg Am (1973) 2.21

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Nat Genet (2013) 1.90

The pathogenesis of adolescent idiopathic scoliosis: review of the literature. Spine (Phila Pa 1976) (2008) 1.88

A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. Nat Genet (2011) 1.86

Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes. Hum Mol Genet (2011) 1.83

MaCH-admix: genotype imputation for admixed populations. Genet Epidemiol (2012) 1.77

A noncoding RNA antisense to moesin at 5p14.1 in autism. Sci Transl Med (2012) 1.51

The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation. Development (1992) 1.39

Adolescent idiopathic scoliosis: prevalence and natural history. Instr Course Lect (1989) 1.23

Genetic association of complex traits: using idiopathic scoliosis as an example. Clin Orthop Relat Res (2007) 1.21

Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood. Curr Genomics (2008) 1.20

Cause and natural history of adolescent idiopathic scoliosis. Orthop Clin North Am (1999) 1.18

Promoter polymorphism of matrilin-1 gene predisposes to adolescent idiopathic scoliosis in a Chinese population. Eur J Hum Genet (2008) 1.17

Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis. Spine (Phila Pa 1976) (2002) 1.17

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. J Orthop Res (2011) 1.17

SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. J Hum Genet (2012) 1.07

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update. Arch Toxicol (2015) 1.06

A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One (2010) 1.02

PTHrP and Bcl-2: essential regulatory molecules in chondrocyte differentiation and chondrogenic tumors. Verh Dtsch Ges Pathol (1998) 1.02

The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. Cancer Biol Ther (2006) 1.01

Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes. J Orthop Res (2010) 1.01

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population. Eur Spine J (2012) 1.01

Histomorphometric study of the spinal growth plates in idiopathic scoliosis and congenital scoliosis. Pediatr Int (2006) 0.99

Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. Mol Biol Cell (2003) 0.98

Neuromuscular scoliosis. PM R (2013) 0.98

Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. Dev Dyn (2001) 0.97

N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2. J Cell Physiol (2000) 0.95

A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases. Spine (Phila Pa 1976) (2006) 0.95

The natural history of spine curvature progression in the nonambulatory Duchenne muscular dystrophy patient. Spine (Phila Pa 1976) (1983) 0.92

The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. Stud Health Technol Inform (2006) 0.92

Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population. PLoS One (2013) 0.89

The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int J Exp Pathol (1998) 0.89

A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females. Nat Commun (2015) 0.88

Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. Mol Cancer Res (2012) 0.88

T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm. J Biol Chem (2008) 0.88

Transforming growth factor beta 1 is a novel susceptibility gene for adolescent idiopathic scoliosis. Spine (Phila Pa 1976) (2013) 0.88

Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors. J Cell Sci (2010) 0.88

Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study. BMC Musculoskelet Disord (2014) 0.87

Histomorphological study of the spinal growth plates from the convex side and the concave side in adolescent idiopathic scoliosis. J Orthop Surg Res (2007) 0.86

Apoptosis and cell proliferation: correlation with BCL-2 and P53 oncoprotein expression in human hepatocellular carcinoma. Hepatogastroenterology (2014) 0.85

Role of neural-cadherin in early osteoblastic differentiation of human bone marrow stromal cells cocultured with human umbilical vein endothelial cells. Am J Physiol Cell Physiol (2010) 0.84

Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. Cell Tissue Res (1997) 0.84

Crystal structure of the EphA4 protein tyrosine kinase domain in the apo- and dasatinib-bound state. FEBS Lett (2011) 0.81

Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis. J Genet Genomics (2011) 0.81

YY1 binds to α-synuclein 3'-flanking region SNP and stimulates antisense noncoding RNA expression. J Hum Genet (2013) 0.80

Associations between matrilin-1 gene polymorphisms and adolescent idiopathic scoliosis curve patterns in a Korean population. Mol Biol Rep (2011) 0.78