Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer.

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Published in Sci Rep on September 24, 2015

Authors

Kenichi Suda1,2, Isao Murakami3, Kazuko Sakai4, Hiroshi Mizuuchi1, Shigeki Shimizu5, Katsuaki Sato1, Kenji Tomizawa1, Shuta Tomida4, Yasushi Yatabe6, Kazuto Nishio4, Tetsuya Mitsudomi1

Author Affiliations

1: Division of Thoracic Surgery, Department of Surgery, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
2: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
3: Department of Respiratory Medicine, Higashi-Hiroshima Medical Center, Higashi-Hiroshima, Japan.
4: Department of Genome Biology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
5: Division of Molecular Pathology, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
6: Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.

Associated clinical trials:

Transformation Into Small Cell Lung Cancer : a Mode of Resistance to Treatment (TransCPC) | NCT03419286

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