The KT Jeang Retrovirology prize 2015: Paul Bieniasz.

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature (2008) 14.99

A diverse range of gene products are effectors of the type I interferon antiviral response. Nature (2011) 12.86

HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nat Med (2001) 8.38

Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat Med (2003) 5.97

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha. Proc Natl Acad Sci U S A (2004) 5.15

Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell (2009) 5.06

Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol (2008) 4.72

Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism. Proc Natl Acad Sci U S A (2002) 4.66

Plasma membrane is the site of productive HIV-1 particle assembly. PLoS Biol (2006) 4.43

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A (2003) 4.21

Restriction of multiple divergent retroviruses by Lv1 and Ref1. EMBO J (2003) 4.19

Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants. PLoS Pathog (2009) 4.18

An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe (2007) 4.17

Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host Microbe (2009) 4.11

HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane. PLoS Pathog (2006) 3.97

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host Microbe (2009) 3.58

Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity. J Virol (2005) 3.54

Role of ESCRT-I in retroviral budding. J Virol (2003) 3.36

APOBEC3G incorporation into human immunodeficiency virus type 1 particles. J Virol (2004) 3.17

Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. EMBO J (1998) 3.05

Imaging the biogenesis of individual HIV-1 virions in live cells. Nature (2008) 2.92

HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J (1997) 2.86

Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. J Virol (2000) 2.72

Reconstitution of an infectious human endogenous retrovirus. PLoS Pathog (2007) 2.52

Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity. J Virol (2005) 2.47

MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature (2013) 2.40

Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid. J Virol (2004) 2.37

HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway. J Cell Biol (2004) 2.34

Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species. Proc Natl Acad Sci U S A (2008) 2.23

Dynamics of ESCRT protein recruitment during retroviral assembly. Nat Cell Biol (2011) 2.23

Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection. J Virol (2002) 2.11

Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles. Proc Natl Acad Sci U S A (2009) 2.08

Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis. Cell (2014) 2.01

Human immunodeficiency virus type 1 matrix inhibits and confers cooperativity on gag precursor-membrane interactions. J Virol (2004) 1.94

Generation of simian-tropic HIV-1 by restriction factor evasion. Science (2006) 1.84

Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription. Proc Natl Acad Sci U S A (1999) 1.82

A macaque model of HIV-1 infection. Proc Natl Acad Sci U S A (2009) 1.76

Analysis of the initiating events in HIV-1 particle assembly and genome packaging. PLoS Pathog (2010) 1.66

Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 1.56

Ubiquitin-dependent virus particle budding without viral protein ubiquitination. Proc Natl Acad Sci U S A (2007) 1.51

Hypermutation of an ancient human retrovirus by APOBEC3G. J Virol (2008) 1.50

Cell cycle dependence of foamy retrovirus infection. J Virol (1995) 1.45

A comparative study of higher primate foamy viruses, including a new virus from a gorilla. Virology (1995) 1.37

Extreme genetic fragility of the HIV-1 capsid. PLoS Pathog (2013) 1.35

Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. J Biol Chem (2004) 1.28

Mechanism of HIV-1 virion entrapment by tetherin. PLoS Pathog (2013) 1.24

Host and viral determinants of Mx2 antiretroviral activity. J Virol (2014) 1.23

Vpu binds directly to tetherin and displaces it from nascent virions. PLoS Pathog (2013) 1.21

SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release. PLoS Pathog (2011) 1.20

Fates of retroviral core components during unrestricted and TRIM5-restricted infection. PLoS Pathog (2013) 1.13

Inhibition of HIV-1 particle assembly by 2',3'-cyclic-nucleotide 3'-phosphodiesterase. Cell Host Microbe (2012) 1.09

Matrix-induced inhibition of membrane binding contributes to human immunodeficiency virus type 1 particle assembly defects in murine cells. J Virol (2005) 1.05

Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathog (2011) 1.05

Gene transfer using replication-defective human foamy virus vectors. Virology (1997) 1.03

Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteins. PLoS Pathog (2008) 0.99

Variable relationship between proviral DNA load and infectious virus titre in the peripheral blood mononuclear cells of HIV-1-infected individuals. AIDS (1993) 0.97

HIV-1-induced AIDS in monkeys. Science (2014) 0.97

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins. Cell Host Microbe (2014) 0.96

Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathog (2013) 0.90

Uneven genetic robustness of HIV-1 integrase. J Virol (2014) 0.88

Identification of a receptor for an extinct virus. Proc Natl Acad Sci U S A (2010) 0.84

Single-Cell and Single-Cycle Analysis of HIV-1 Replication. PLoS Pathog (2015) 0.80

The KT Jeang Retrovirology prize 2016: Frank Kirchhoff. Retrovirology (2016) 0.75

The KT Jeang Retrovirology prize 2017: Michael Emerman. Retrovirology (2017) 0.75